C57BL/6NCya-Tex30em1/Cya
Common Name
Tex30-KO
Product ID
S-KO-14694
Backgroud
C57BL/6NCya
Strain ID
KOCMP-75623-Tex30-B6N-VA
When using this mouse strain in a publication, please cite “Tex30-KO Mouse (Catalog S-KO-14694) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tex30-KO
Strain ID
KOCMP-75623-Tex30-B6N-VA
Gene Name
Product ID
S-KO-14694
Gene Alias
1700029F09Rik, 3110030D08Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 1
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000027215
NCBI RefSeq
NM_029368
Target Region
Exon 5~6
Size of Effective Region
~3.1 kb
Overview of Gene Research
Tex30, also known as Testis expressed 30, is one of the "testis expressed" genes. However, the exact function, associated pathways, and its overall biological importance remain to be fully elucidated. Genetic models, such as gene knockout models, could potentially help in understanding its role more comprehensively.
In a study screening exome sequencing data of 1305 men including infertile individuals and generating testis-specific knockdown (KD) models of orthologous TEX genes in Drosophila melanogaster, the KD of Tex30 in Drosophila resulted in normal fertility [1].
In conclusion, based on the Drosophila knockdown model, Tex30 does not seem to be essential for fertility in Drosophila. Although more research is needed, this finding from the in vivo Drosophila model provides a starting point for understanding the role of Tex30, especially in the context of male fertility-related biological processes.
References:
1. Sieper, Marie H, Gaikwad, Avinash S, Fros, Marion, Tüttelmann, Frank, Wyrwoll, Margot J. 2023. Scrutinizing the human TEX genes in the context of human male infertility. In Andrology, 12, 570-584. doi:10.1111/andr.13511. https://pubmed.ncbi.nlm.nih.gov/37594251/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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