Actrt3, though specific aliases are not mentioned in the provided references, seems to be involved in telomere maintenance pathways [1,3]. Telomere maintenance is crucial for genomic stability, and thus Actrt3 may play an important role in maintaining the integrity of the genome, which is essential for normal cellular function and development.

In a cross-ancestry genome-wide association study (GWAS) and transcriptome-wide association study (TWAS), associations were detected between Actrt3 (located in the 3q26 region) and the development of multiple primary cancers. This indicates that Actrt3 might contribute to the genetic susceptibility to multiple cancers, potentially through its role in telomere maintenance [1,3]. In another study assessing B cell activation, Actrt3 was determined as a crucial gene in the Be1 network, suggesting its involvement in the immune system activation [2].

In conclusion, Actrt3 appears to be involved in important biological functions such as telomere maintenance and immune system activation. Its association with the development of multiple primary cancers from model-based research (GWAS and TWAS) highlights its significance in understanding the genetic basis of cancer susceptibility. This knowledge could potentially contribute to the development of targeted prevention and intervention strategies for multiple cancers [1,2,3].

References:

1. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2024. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In medRxiv : the preprint server for health sciences, , . doi:10.1101/2024.10.29.24316326. https://pubmed.ncbi.nlm.nih.gov/39574869/

2. Fatehi, Razieh. . Assessment of the genes and molecular mechanisms of B cells activation through systems biology approaches. In Human antibodies, 28, 83-87. doi:10.3233/HAB-190393. https://pubmed.ncbi.nlm.nih.gov/31524152/

3. Middha, Pooja, Kachuri, Linda, Nierenberg, Jovia L, Sakoda, Lori C, Witte, John S. 2025. Unraveling the genetic landscape of susceptibility to multiple primary cancers. In HGG advances, 6, 100413. doi:10.1016/j.xhgg.2025.100413. https://pubmed.ncbi.nlm.nih.gov/39910817/