C57BL/6JCya-Krtap19-3em1/Cya
Common Name
Krtap19-3-KO
Product ID
S-KO-15109
Backgroud
C57BL/6JCya
Strain ID
KOCMP-77918-Krtap19-3-B6J-VA
When using this mouse strain in a publication, please cite “Krtap19-3-KO Mouse (Catalog S-KO-15109) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Krtap19-3-KO
Strain ID
KOCMP-77918-Krtap19-3-B6J-VA
Gene Name
Product ID
S-KO-15109
Gene Alias
A030006N06Rik, Krtap16-5
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 16
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000075284
NCBI RefSeq
NM_130857
Target Region
Exon 1
Size of Effective Region
~2.0 kb
Overview of Gene Research
Krtap19-3 is a new member of the KAP19 gene family in sheep. While its exact function and associated pathways are not fully elaborated in the given reference, understanding genes like Krtap19-3 is crucial as genetic improvement can address challenges in wool processing industries related to fibre trait variation [1].
Phylogenetic analysis showed its relationship with other known KRTAP19 gene sequences. Analysis of nucleotide sequence variation in Krtap19-3 from 288 sheep of various breeds revealed six unique variant sequences, with eleven single nucleotide polymorphisms (SNPs), six in the coding region and three non-synonymous causing amino acid changes. In Chinese Tan sheep, specific sequence variants were associated with wool trait variation, especially an increase in fibre diameter variability in heterotypic hair fibres [1].
In summary, Krtap19-3 is a gene within the KAP19 family in sheep that appears to have an impact on wool traits, as shown by sequence variant-wool trait associations. These findings contribute to our understanding of genes encoding sheep wool proteins, potentially aiding in genetic improvement strategies for the wool industry [1].
References:
1. Bai, Lingrong, Zhou, Huitong, Tao, Jinzhong, Hickford, Jon G H. 2024. Characterisation of Ovine KRTAP19-3 and Its Impact on Wool Traits in Chinese Tan Sheep. In Animals : an open access journal from MDPI, 14, . doi:10.3390/ani14192772. https://pubmed.ncbi.nlm.nih.gov/39409721/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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