Krtap19-3 is a new member of the KAP19 gene family in sheep. While its exact function and associated pathways are not fully elaborated in the given reference, understanding genes like Krtap19-3 is crucial as genetic improvement can address challenges in wool processing industries related to fibre trait variation [1].

Phylogenetic analysis showed its relationship with other known KRTAP19 gene sequences. Analysis of nucleotide sequence variation in Krtap19-3 from 288 sheep of various breeds revealed six unique variant sequences, with eleven single nucleotide polymorphisms (SNPs), six in the coding region and three non-synonymous causing amino acid changes. In Chinese Tan sheep, specific sequence variants were associated with wool trait variation, especially an increase in fibre diameter variability in heterotypic hair fibres [1].

In summary, Krtap19-3 is a gene within the KAP19 family in sheep that appears to have an impact on wool traits, as shown by sequence variant-wool trait associations. These findings contribute to our understanding of genes encoding sheep wool proteins, potentially aiding in genetic improvement strategies for the wool industry [1].

References:

1. Bai, Lingrong, Zhou, Huitong, Tao, Jinzhong, Hickford, Jon G H. 2024. Characterisation of Ovine KRTAP19-3 and Its Impact on Wool Traits in Chinese Tan Sheep. In Animals : an open access journal from MDPI, 14, . doi:10.3390/ani14192772. https://pubmed.ncbi.nlm.nih.gov/39409721/