Pgpep1l is a gene whose exact function, common aliases, and associated pathways are not clearly detailed in the provided references. However, its biological importance might be inferred from its associations in the research [1,2,3].

In the first study, an eight-gene signature including PGPEP1L was proposed for colorectal cancer, suggesting its potential role in carcinogenesis and prognosis prediction at the molecular level [1]. In chicken research, circ-ITSN2 in liver tissue was significantly positively correlated with PGPEP1L, which was associated with heterosis for feed intake and efficiency [2]. Additionally, in a study on late-onset Alzheimer's disease, PGPEP1L was among the genes with differential DNA methylation patterns in peripheral blood leukocytes, indicating its potential as a biomarker for the disease [3].

In summary, PGPEP1L shows potential significance in multiple biological contexts. In colorectal cancer, it could be involved in carcinogenesis and prognosis. In chickens, it may be related to heterosis in feed-related traits. And in Alzheimer's disease, it might be linked to epigenetic changes in blood cells, highlighting its potential value in biomarker discovery for these disease areas.

References:

1. Gong, Benjiao, Kao, Yanlei, Zhang, Chenglin, Gong, Zhaohua, Chen, Jian. 2020. Identification of Hub Genes Related to Carcinogenesis and Prognosis in Colorectal Cancer Based on Integrated Bioinformatics. In Mediators of inflammation, 2020, 5934821. doi:10.1155/2020/5934821. https://pubmed.ncbi.nlm.nih.gov/32351322/

2. Yuan, Jingwei, Li, Qin, Sun, Yanyan, Ma, Hui, Chen, Jilan. 2024. Multi-tissue transcriptome profiling linked the association between tissue-specific circRNAs and the heterosis for feed intake and efficiency in chicken. In Poultry science, 103, 103783. doi:10.1016/j.psj.2024.103783. https://pubmed.ncbi.nlm.nih.gov/38713987/

3. Chacón, Tatiana, Hernández, Hernán G. 2025. DNA methylation in peripheral blood leukocytes in late onset Alzheimer's disease. In Journal of Alzheimer's disease reports, 9, 25424823251341176. doi:10.1177/25424823251341176. https://pubmed.ncbi.nlm.nih.gov/40343304/