C57BL/6JCya-Cd163em1/Cya
Common Name
Cd163-KO
Product ID
S-KO-15439
Backgroud
C57BL/6JCya
Strain ID
KOCMP-93671-Cd163-B6J-VA
When using this mouse strain in a publication, please cite “Cd163-KO Mouse (Catalog S-KO-15439) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Cd163-KO
Strain ID
KOCMP-93671-Cd163-B6J-VA
Gene Name
Product ID
S-KO-15439
Gene Alias
CD163v2, CD163v3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 6
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000112541
NCBI RefSeq
NM_001170395
Target Region
Exon 3~15
Size of Effective Region
~21.0 kb
Overview of Gene Research
CD163 is an endocytic receptor mainly expressed in a subpopulation of macrophages. It serves as a scavenger receptor, with a quantitatively important ligand being the haptoglobin-hemoglobin complex. CD163 is involved in multiple biological processes, including endocytosis, phagocytosis, and signaling during inflammation. It is also part of the TWEAK/Fn14/CD163 axis which controls various cellular events such as proliferation, migration, and apoptosis [1,2].
In a study using ApoE -/- CD163 -/- mice, CD163+ macrophages were found to inhibit vascular calcification through NF-κB-induced hyaluronan synthase (HAS) augmentation, promoting the development of high-risk atherosclerotic plaques. The absence of CD163 in these mice led to greater vascular calcification, indicating the role of CD163+ macrophages in restraining this process [3].
In conclusion, CD163 is a crucial receptor in macrophages, playing a significant role in inflammation-related processes and disease development. The use of gene-knockout mouse models, like the ApoE -/- CD163 -/- mice, has provided valuable insights into the role of CD163 in vascular calcification and atherosclerotic plaque development, highlighting its importance in understanding these disease mechanisms.
References:
1. Skytthe, Maria K, Graversen, Jonas Heilskov, Moestrup, Søren K. 2020. Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases. In International journal of molecular sciences, 21, . doi:10.3390/ijms21155497. https://pubmed.ncbi.nlm.nih.gov/32752088/
2. Ratajczak, Wiktoria, Atkinson, Sarah D, Kelly, Catriona. 2021. The TWEAK/Fn14/CD163 axis-implications for metabolic disease. In Reviews in endocrine & metabolic disorders, 23, 449-462. doi:10.1007/s11154-021-09688-4. https://pubmed.ncbi.nlm.nih.gov/34542797/
3. Sakamoto, Atsushi, Kawakami, Rika, Mori, Masayuki, Virmani, Renu, Finn, Aloke V. 2023. CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque. In JCI insight, 8, . doi:10.1172/jci.insight.154922. https://pubmed.ncbi.nlm.nih.gov/36719758/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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