C57BL/6JCya-Pcdhgb1em1/Cya
Common Name:
Pcdhgb1-KO
Product ID:
S-KO-15457
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Pcdhgb1-KO
Strain ID
KOCMP-93699-Pcdhgb1-B6J-VA
Gene Name
Product ID
S-KO-15457
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
18
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Pcdhgb1em1/Cya mice (Catalog S-KO-15457) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000192931
NCBI RefSeq
NM_033574
Target Region
Exon 1
Size of Effective Region
~3 kb
Detailed Document
Overview of Gene Research
Pcdhgb1, a member of the protocadherin gamma subfamily B, is involved in neural development, synapse function, and memory. It likely participates in cadherin-related signaling pathways, which are crucial for cell-cell adhesion and communication in the nervous system [3]. Understanding its function can provide insights into normal neural development and associated disease mechanisms.
In a study where Brpf1 was knocked out in forebrain excitatory neurons of mice, the expression of Pcdhgb1 was downregulated. This deficiency led to reduced frequency of miniature excitatory postsynaptic currents and impaired spatial and fear memory, suggesting Pcdhgb1 has a role in maintaining normal synaptic transmission and memory function [3]. In patients with adult-onset dystonia, whole-exome sequencing identified rare variants in Pcdhgb1, indicating its potential involvement in this movement disorder [1]. Also, in chronic rhinosinusitis, the transcript of Pcdhgb1 was upregulated in response to systemic corticosteroid therapy in nasal polyp biopsies [2].
In conclusion, Pcdhgb1 is important for neural-related functions such as synaptic transmission and memory. Studies on gene knockout mouse models, like the Brpf1 -deficient mice, have revealed its role in these processes. Its association with adult-onset dystonia and response to corticosteroid therapy in chronic rhinosinusitis further suggest its significance in understanding and potentially treating these disease conditions.
References:
1. Li, Li-Xi, Huang, Jie-Hong, Pan, Li-Zhen, Pan, You-Gui, Jin, Ling-Jing. 2022. Whole-Exome Sequencing Identified Rare Variants in PCDHGB1 in Patients with Adult-Onset Dystonia. In Movement disorders : official journal of the Movement Disorder Society, 37, 1099-1101. doi:10.1002/mds.28965. https://pubmed.ncbi.nlm.nih.gov/35229923/
2. Hoggard, Michael, Jacob, Bincy, Wheeler, David, Douglas, Richard G, Taylor, Michael W. 2020. Multiomic analysis identifies natural intrapatient temporal variability and changes in response to systemic corticosteroid therapy in chronic rhinosinusitis. In Immunity, inflammation and disease, 9, 90-107. doi:10.1002/iid3.349. https://pubmed.ncbi.nlm.nih.gov/33220024/
3. Zhao, Baicheng, Zhang, Hang, Liu, Ying, Liu, Shuai, You, Linya. . Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory. In Neural regeneration research, 19, 1133-1141. doi:10.4103/1673-5374.385307. https://pubmed.ncbi.nlm.nih.gov/37862219/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen