C57BL/6JCya-Tm2d1em1/Cya
Common Name
Tm2d1-KO
Product ID
S-KO-15520
Backgroud
C57BL/6JCya
Strain ID
KOCMP-94043-Tm2d1-B6J-VA
When using this mouse strain in a publication, please cite “Tm2d1-KO Mouse (Catalog S-KO-15520) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Tm2d1-KO
Strain ID
KOCMP-94043-Tm2d1-B6J-VA
Gene Name
Product ID
S-KO-15520
Gene Alias
2310026L18Rik, Bbp
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 4
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000102793
NCBI RefSeq
NM_053157.2
Target Region
Exon 3
Size of Effective Region
~1.2 kb
Overview of Gene Research
Tm2d1, also known as β -amyloid peptide binding protein, is critical to the pathogenesis of Alzheimer's disease (AD). It may be involved in the intracellular signaling pathways related to β -amyloid peptide-induced neuronal cell death, though it doesn't directly couple to Gα(i/o), Gα(s), or Gα(q) proteins [3,4].
In hepatocellular carcinoma (HCC), TM2D1 is increasingly expressed in tumors compared to peritumoral tissues. Overexpression of TM2D1 promotes HCC cell proliferation, migration, and invasion, related to epithelial-mesenchymal transition (EMT) by activating the AKT/β-catenin axis. Depletion of TM2D1 leads to the opposite phenotype [1]. In colorectal cancer, sevoflurane and propofol co-treatment affects cancer cell biology behaviors such as apoptosis, ferroptosis, proliferation, invasion, and migration, with TM2D1 considered a target. Overexpression of TM2D1 reverses these effects [2].
In conclusion, Tm2d1 plays important roles in the development of certain cancers. In HCC, it promotes EMT through the AKT/β-catenin axis, and in colorectal cancer, it is involved in the anti-tumor mechanism of sevoflurane and propofol. These findings suggest Tm2d1 could be a potential therapeutic target for these cancers.
References:
1. Hu, Jin-Wu, Yin, Yue, Gao, Yang, Fan, Jia, Zhou, Jian. 2021. TM2D1 contributes the epithelial-mesenchymal transition of hepatocellular carcinoma via modulating AKT/β-catenin axis. In American journal of cancer research, 11, 1557-1571. doi:. https://pubmed.ncbi.nlm.nih.gov/33948373/
2. Lu, Yan, Li, Ling, Piao, Zongfang, Tan, Xinmin, Su, Rui. 2024. Sevoflurane and Propofol Co-affect the Development of Colorectal Cancer by Regulating TM2D1. In Combinatorial chemistry & high throughput screening, , . doi:10.2174/0113862073281046240527165415. https://pubmed.ncbi.nlm.nih.gov/38920064/
3. Lee, Yong, Chang, Deok-Jin, Lee, Yong-Seok, Suh, Yoo-Hun, Kaang, Bong-Kiun. . Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system. In Journal of neuroscience research, 73, 255-9. doi:. https://pubmed.ncbi.nlm.nih.gov/12836168/
4. Kajkowski, E M, Lo, C F, Ning, X, Jacobsen, J S, Ozenberger, B A. 2001. beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. In The Journal of biological chemistry, 276, 18748-56. doi:. https://pubmed.ncbi.nlm.nih.gov/11278849/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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