Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Eps8l2em1/Cya
Common Name:
Eps8l2-KO
Product ID:
S-KO-15637
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Eps8l2-KO
Strain ID
KOCMP-98845-Eps8l2-B6J-VA
Gene Name
Eps8l2
Product ID
S-KO-15637
Gene Alias
Eps8r2
Background
C57BL/6JCya
NCBI ID
98845
Modification
Conventional knockout
Chromosome
7
Phenotype
MGI:2138828
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Eps8l2em1/Cya mice (Catalog S-KO-15637) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000026577
NCBI RefSeq
NM_133191
Target Region
Exon 5~15
Size of Effective Region
~4.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Eps8l2, Epidermal growth factor receptor Pathway Substrate 8 L2, is an actin-binding protein. It is part of a family of proteins that link growth factor stimulation to actin reorganization, participating in the Ras/Rac pathway [5]. Eps8l2 is important for the maintenance of actin-based structures in various biological processes, and its function is relevant in cell migration, inner ear hair cell integrity, and potentially in meat traits of chickens [1,4,6].

In cell migration, Ctdnep1 and Eps8L2 directly interact, and this interaction is crucial for nuclear positioning. They are involved in the formation and thickness of dorsal actin cables required for TAN lines engagement during nuclear movement [1]. In the inner ear, Eps8L2 null-mutant mice display a late-onset, progressive hearing loss due to the gradual deterioration of hair bundle morphology, indicating its requirement for the long-term maintenance of auditory hair bundle structure and function [4]. In Rhodesian Ridgeback dogs, an in-frame deletion in EPS8L2 is associated with early onset adult deafness [3]. In humans, a frame-shift variant in EPS8L2 causes childhood-onset autosomal recessive progressive hearing loss [2].

In conclusion, Eps8l2 plays essential roles in cell migration-related nuclear positioning and the maintenance of inner ear hair cell function. Studies using gene-knockout mouse models and animal disease models have revealed its significance in these biological processes and in hereditary hearing disorders. Understanding Eps8l2 contributes to our knowledge of normal biological functions and the underlying mechanisms of related diseases.

References:

1. Calero-Cuenca, Francisco J, Osorio, Daniel S, Carvalho-Marques, Sofia, Cadot, Bruno, Gomes, Edgar R. 2021. Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration. In Current biology : CB, 31, 1521-1530.e8. doi:10.1016/j.cub.2021.01.007. https://pubmed.ncbi.nlm.nih.gov/33567288/

2. Dahmani, Malika, Ammar-Khodja, Fatima, Bonnet, Crystel, Mallek, Zahia, Petit, Christine. 2015. EPS8L2 is a new causal gene for childhood onset autosomal recessive progressive hearing loss. In Orphanet journal of rare diseases, 10, 96. doi:10.1186/s13023-015-0316-8. https://pubmed.ncbi.nlm.nih.gov/26282398/

3. Kawakami, Takeshi, Raghavan, Vandana, Ruhe, Alison L, Nelson, Thomas C, Boyko, Adam R. 2022. Early onset adult deafness in the Rhodesian Ridgeback dog is associated with an in-frame deletion in the EPS8L2 gene. In PloS one, 17, e0264365. doi:10.1371/journal.pone.0264365. https://pubmed.ncbi.nlm.nih.gov/35385474/

4. Furness, David N, Johnson, Stuart L, Manor, Uri, Kachar, Bechara, Marcotti, Walter. 2013. Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2. In Proceedings of the National Academy of Sciences of the United States of America, 110, 13898-903. doi:10.1073/pnas.1304644110. https://pubmed.ncbi.nlm.nih.gov/23918390/

5. Offenhäuser, Nina, Borgonovo, Alessandro, Disanza, Andrea, Di Fiore, Pier Paolo, Scita, Giorgio. 2003. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. In Molecular biology of the cell, 15, 91-8. doi:. https://pubmed.ncbi.nlm.nih.gov/14565974/

6. Tian, Shuaishuai, Tang, Wendan, Zhong, Ziqi, Tan, Zhen, Xiao, Qian. 2023. Identification of Runs of Homozygosity Islands and Functional Variants in Wenchang Chicken. In Animals : an open access journal from MDPI, 13, . doi:10.3390/ani13101645. https://pubmed.ncbi.nlm.nih.gov/37238076/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest