ACTRT2, the Actin Related Protein T2, is an actin-binding-related protein. It is likely involved in cytoskeletal regulation, which is crucial for various cellular processes. Proteins like ACTRT2 that are related to the cytoskeleton play a part in maintaining cell structure and facilitating cell movement. Genetic models, such as knockout mouse models, could potentially be valuable for further exploring its function [3].

In obesity-associated asthenozoospermia, the expression of ACTRT2 in spermatozoa declines, which may contribute to sperm quality defects and reduced sperm motility. ACTRT2 is localized in the post-acrosomal region and middle piece of human spermatozoa [1]. Additionally, in the context of transient scrotal hyperthermia, the expression of ACTRT2 in sperm tended to be reduced, suggesting its role in heat-induced reversible reduction in sperm concentration and motility, and its potential as a biomarker and clinical target for scrotal heat treatment-induced male infertility [2].

In conclusion, ACTRT2 plays an important role in sperm-related functions. Studies related to its reduced expression in conditions like obesity-associated asthenozoospermia and transient scrotal hyperthermia highlight its significance in maintaining sperm quality and motility. The use of genetic models could potentially further elucidate its role in these and other related biological processes and disease conditions.

References:

1. Liu, Y, Guo, Y, Song, N, Guo, Q, Ding, Z. 2014. Proteomic pattern changes associated with obesity-induced asthenozoospermia. In Andrology, 3, 247-59. doi:10.1111/andr.289. https://pubmed.ncbi.nlm.nih.gov/25293813/

2. Wu, Yan-Qing, Rao, Meng, Hu, Shi-Fu, Zhu, Chang-Hong, Xia, Wei. 2020. Effect of transient scrotal hyperthermia on human sperm: an iTRAQ-based proteomic analysis. In Reproductive biology and endocrinology : RB&E, 18, 83. doi:10.1186/s12958-020-00640-w. https://pubmed.ncbi.nlm.nih.gov/32787870/

3. Thami, Prisca K, Choga, Wonderful T, Dandara, Collet, Gaseitsiwe, Simani, Chimusa, Emile R. 2023. Whole genome sequencing reveals population diversity and variation in HIV-1 specific host genes. In Frontiers in genetics, 14, 1290624. doi:10.3389/fgene.2023.1290624. https://pubmed.ncbi.nlm.nih.gov/38179408/