C57BL/6JCya-Mir22em1/Cya
Common Name
Mir22-KO
Product ID
S-KO-15844
Backgroud
C57BL/6JCya
Strain ID
KOCMP-387141-Mir22-B6J-VA
When using this mouse strain in a publication, please cite “Mir22-KO Mouse (Catalog S-KO-15844) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Mir22-KO
Strain ID
KOCMP-387141-Mir22-B6J-VA
Gene Name
Product ID
S-KO-15844
Gene Alias
Mirn22, mmu-mir-22
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 11
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000083595
NCBI RefSeq
NR_029739
Target Region
Exon 1
Size of Effective Region
~1.7 kb
Overview of Gene Research
Mir22, an endogenous microRNA, is involved in post-transcriptional regulation of gene expression, playing a role in diverse biological processes. Its dysregulation is associated with various diseases. It participates in epigenetic pathways and is part of gene regulatory axes, highlighting its biological importance [1,2]. Genetic models, such as gene knockout mice, are valuable for studying Mir22's functions.
In a study on rheumatoid arthritis (RA), Mir22-/-mice were used to establish a collagen antibody-induced arthritis (CAIA) model. Results showed that MIR22 inhibits inflammation in fibroblast-like synoviocytes (FLSs) of RA patients by directly inhibiting the translation of TET3, which in turn affects the pro-inflammatory effect on MTRNR2L2 through 5-hydroxymethylcytosine production. This reveals the key role of the MIR22-TET3-MTRNR2L2 pathway in RA-FLSs [1]. In another study, in a mouse model of dopaminergic neuron-related disease, dysregulation of the SATB1-MIR22-GBA axis led to glucocerebroside accumulation, causing a cellular senescence-like phenotype in dopaminergic neurons [2].
In conclusion, Mir22 is crucial in regulating gene expression and has a significant impact on biological processes related to diseases like rheumatoid arthritis and Parkinson's disease-related dopaminergic neuron phenotypes. Gene knockout mouse models have been instrumental in uncovering these functions, providing insights into disease pathogenesis and potential therapeutic targets.
References:
1. Fang, Yilong, Huang, Wei, Zhu, Xiangling, Tu, Jiajie, Zhu, Chen. 2024. Epigenetic Regulatory Axis MIR22-TET3-MTRNR2L2 Represses Fibroblast-Like Synoviocyte-Mediated Inflammation in Rheumatoid Arthritis. In Arthritis & rheumatology (Hoboken, N.J.), 76, 845-856. doi:10.1002/art.42795. https://pubmed.ncbi.nlm.nih.gov/38221658/
2. Russo, Taylor, Kolisnyk, Benjamin, B S, Aswathy, Studer, Lorenz, Riessland, Markus. 2024. The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons. In Aging cell, 23, e14077. doi:10.1111/acel.14077. https://pubmed.ncbi.nlm.nih.gov/38303548/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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