C57BL/6JCya-Ctnnd2em1/Cya
Common Name
Ctnnd2-KO
Product ID
S-KO-16053
Backgroud
C57BL/6JCya
Strain ID
KOCMP-18163-Ctnnd2-B6J-VB
Status
When using this mouse strain in a publication, please cite “Ctnnd2-KO Mouse (Catalog S-KO-16053) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Ctnnd2-KO
Strain ID
KOCMP-18163-Ctnnd2-B6J-VB
Gene Name
Product ID
S-KO-16053
Gene Alias
Nprap, Catnd2, neurojugin
Background
C57BL/6JCya
Gene Full Name
catenin (cadherin associated protein), delta 2
Modification
Conventional knockout
NCBI ID
Phenotype
Chromosome
Chr 15 (Mouse)
Application
--
Datasheet
Strain Description
Ensembl Transcript ID
ENSMUST00000081728
NCBI Transcript ID
NM_008729.3
Target Region
Exon 3
Size of Effective Region
~1.1 kb
Overview of Gene Research
Ctnnd2, also known as δ -catenin/NPRAP/Neurojungin, is an adhesive junction-associated protein in the delta subfamily of the β-catenin superfamily. It functions in Wnt signaling to regulate gene expression and modulate Rho GTPases of the Ras superfamily in cytoskeletal reorganization. Ctnnd2 is likely a key point where Wnt signaling meets Rho GTPases and is important for processes like synaptic function and neuronal development [1].
In mice, Ctnnd2-Knock out (KO) mice exhibit typical autism-like behaviors, such as reduced social interaction and more frequent stereotypic behaviors. They also have deficits in spatial learning and memory, with decreased actin polymerization and postsynaptic spine density in hippocampal CA1 neurons. ShRNA-induced knockdown of Rictor, a protein with reduced expression in Ctnnd2-KO mice, exacerbates spatial learning and memory deficits but not autism-like behaviors, suggesting Ctnnd2 is involved in spatial learning and memory via Rictor-mediated actin polymerization and synaptic plasticity [2]. Additionally, chronic sleep restriction in Ctnnd2 KO mice further impairs social ability, cognition, and increases repetitive behaviors, while also affecting dendritic spines and the PI3K/Akt-mTOR pathway [3].
In conclusion, Ctnnd2 plays essential roles in synaptic maturation, neuronal integrity, and spatial learning and memory. Mouse KO models have been crucial in revealing its role in autism-like behaviors and cognitive impairments, providing insights into the mechanisms underlying these neurodevelopmental disorders.
References:
1. Lu, Qun, Aguilar, Byron J, Li, Mingchuan, Jiang, Yongguang, Chen, Yan-Hua. 2016. Genetic alterations of δ-catenin/NPRAP/Neurojungin (CTNND2): functional implications in complex human diseases. In Human genetics, 135, 1107-16. doi:10.1007/s00439-016-1705-3. https://pubmed.ncbi.nlm.nih.gov/27380241/
2. Wang, Xiaoya, Xu, Man, Xu, Qingbao, Deng, Jing, Wang, Shali. . Rictor is involved in Ctnnd2 deletion-induced impairment of spatial learning and memory but not autism-like behaviors. In Frontiers in bioscience (Landmark edition), 26, 335-346. doi:10.52586/4947. https://pubmed.ncbi.nlm.nih.gov/34455763/
3. Xu, Man, Wang, Xiaoya, Wang, Luyi, Tao, Yihao, Tan, Shujiang. 2023. Effects of chronic sleep restriction on the neuro-phenotypes of Ctnnd2 knockout mice. In Brain and behavior, 13, e3075. doi:10.1002/brb3.3075. https://pubmed.ncbi.nlm.nih.gov/37226399/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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