Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Trp53em1/Cya
Common Name:
Trp53-KO
Product ID:
S-KO-16097
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Trp53-KO
Strain ID
KOCMP-22059-Trp53-B6N-VB
Gene Name
Trp53
Product ID
S-KO-16097
Gene Alias
Tp53; bbl; bfy; bhy; p44; p53
Background
C57BL/6NCya
NCBI ID
22059
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:98834
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Trp53em1/Cya mice (Catalog S-KO-16097) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000108658
NCBI RefSeq
NM_011640
Target Region
Exon 2~9
Size of Effective Region
~3.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Trp53, the mouse ortholog of the human TP53 gene, is a crucial tumor suppressor gene. Its protein product, p53, is often called the "guardian of the genome" as it regulates multiple key processes including the cell cycle, DNA repair, apoptosis, cellular metabolism, and senescence, thus balancing cell death and proliferation. Mutations or deletions of TP53 lead to loss of p53 activity, which is a common feature in the majority of sporadic cancers. Genetic models, such as knockout and transgenic mice, are valuable tools for studying Trp53.

In Trp53 knockout mouse studies, Trp53 -/- mice showed no mammary gland phenotype initially, but BALB/c-Trp53 -/- mice demonstrated a delayed involution phenotype and a mammary tumor phenotype. This suggests the role of Trp53 in mammary gland involution, and how its loss can contribute to tumorigenesis in cooperation with other factors like hormones, chemical carcinogens, and oncogenic pathways [1]. In another study, dual loss of Rb1 and Trp53 in the mouse adrenal medulla led to the development of bilateral pheochromocytomas, indicating that Trp53 is an efficient genetic modifier of Rb1 loss in the development of this tumor type, while loss of Trp53 alone generally had no effect on adrenal chromaffin cell homeostasis [3].

In conclusion, Trp53 plays a vital role in maintaining genomic stability and preventing tumorigenesis through its regulation of multiple cellular processes. The use of Trp53 knockout mouse models has provided significant insights into its role in diseases such as breast cancer and pheochromocytoma, enhancing our understanding of the underlying molecular mechanisms and potentially guiding the development of targeted therapies.

References:

1. Blackburn, Anneke C, Jerry, D Joseph. 2002. Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer? In Breast cancer research : BCR, 4, 101-11. doi:. https://pubmed.ncbi.nlm.nih.gov/12052252/

2. Merino, Diana, Malkin, David. . p53 and hereditary cancer. In Sub-cellular biochemistry, 85, 1-16. doi:10.1007/978-94-017-9211-0_1. https://pubmed.ncbi.nlm.nih.gov/25201186/

3. Tonks, Ian D, Mould, Arne W, Schroder, Wayne A, Walker, Graeme J, Kay, Graham F. . Dual loss of rb1 and Trp53 in the adrenal medulla leads to spontaneous pheochromocytoma. In Neoplasia (New York, N.Y.), 12, 235-43. doi:. https://pubmed.ncbi.nlm.nih.gov/20234817/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest