C57BL/6JCya-Adrb1em1/Cya
Common Name:
Adrb1-KO
Product ID:
S-KO-16152
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Adrb1-KO
Strain ID
KOCMP-11554-Adrb1-B6J-VA
Gene Name
Product ID
S-KO-16152
Gene Alias
Adrb-1; beta-AR
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
19
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Adrb1em1/Cya mice (Catalog S-KO-16152) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000038949
NCBI RefSeq
NM_007419
Target Region
Exon 1
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
Adrb1, also known as the β1-adrenergic receptor, is a crucial component in the adrenergic signaling pathway. It binds to catecholamines such as epinephrine and norepinephrine, playing a significant role in regulating various physiological processes including heart rate, cardiac contractility, and the body's stress response. It is also involved in immune-related functions, linking the stress-associated catecholamines to the progression of T-cell exhaustion [1].
In a study on T-cell exhaustion, it was found that exhausted CD8+ T-cells increase ADRB1 expression. Exposure of ADRB1+ T-cells to catecholamines suppresses their cytokine production and proliferation. Ablation of β1-adrenergic signalling limits the progression of T-cells towards the exhausted state in chronic infection and improves effector functions when combined with immune checkpoint blockade in melanoma [1].
In conclusion, Adrb1 is essential for multiple physiological and immune-related functions. Its role in regulating T-cell exhaustion, as revealed through functional studies, has significant implications for understanding and potentially treating diseases related to immune dysfunction such as cancer and chronic infections [1].
References:
1. Globig, Anna-Maria, Zhao, Steven, Roginsky, Jessica, Emu, Brinda, Kaech, Susan M. 2023. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion. In Nature, 622, 383-392. doi:10.1038/s41586-023-06568-6. https://pubmed.ncbi.nlm.nih.gov/37731001/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen