Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6NCya-Retnlbem1/Cya
Common Name:
Retnlb-KO
Product ID:
S-KO-16262
Background:
C57BL/6NCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Retnlb-KO
Strain ID
KOCMP-57263-Retnlb-B6N-VA
Gene Name
Retnlb
Product ID
S-KO-16262
Gene Alias
9030012B21Rik; Fizz2; RELMbeta; Relmb; Xcp3
Background
C57BL/6NCya
NCBI ID
57263
Modification
Conventional knockout
Chromosome
16
Phenotype
MGI:1888505
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6NCya-Retnlbem1/Cya mice (Catalog S-KO-16262) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000023328
NCBI RefSeq
NM_023881
Target Region
Exon 3~4
Size of Effective Region
~2.6 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Retnlb, also known as resistin-like molecule beta (RELMbeta), is a bioactive molecule synthesized by intestinal goblet cells [1]. It is involved in the innate host defense of the gastrointestinal tract, as part of the mucus layer which acts as the front line of this defense mechanism.

In a study on hookworm infection using Retnlb -/- mice, it was found that Retnlb can promote the expulsion of the hookworm Nippostrongylus brasiliensis, indicating its role in immunity against such infections [3]. In the context of oral squamous cell carcinoma, data from The Cancer Genome Atlas database showed that Retnlb was upregulated in the tissues and cells of this cancer type. Knockdown of Retnlb significantly reduced the viability, mobility, and invasiveness of cells, suggesting that downregulation of Retnlb may restrain the progression of oral squamous cell carcinoma by inactivating the TLR/2/4/ERK pathway [2]. In colorectal cancer patients, a microarray analysis showed a significant reduction of Retnlb expression in CRC biopsies compared to healthy mucosa, and this reduction was associated with the TNM grade, patients' age, and mutations in KRAS, TP53, and BRAF. Low levels of Retnlb were associated with an unfavorable prognosis [4].

In conclusion, Retnlb plays important roles in immunity and in the progression of certain cancers. The use of gene knockout mouse models has been crucial in revealing its functions in these biological processes and disease conditions, providing valuable insights into its potential as a therapeutic target in oral and colorectal cancers.

References:

1. Kim, Young S, Ho, Samuel B. . Intestinal goblet cells and mucins in health and disease: recent insights and progress. In Current gastroenterology reports, 12, 319-30. doi:10.1007/s11894-010-0131-2. https://pubmed.ncbi.nlm.nih.gov/20703838/

2. Jin, Hong, Miao, Hui, Nie, Yuan-Wen, Lin, Yang-Yang. 2021. Investigating resistin like beta (RETNLB) as a tumor promoter for oral squamous cell carcinoma. In Head & face medicine, 17, 20. doi:10.1186/s13005-021-00272-4. https://pubmed.ncbi.nlm.nih.gov/34158059/

3. Chen, Gang, Wang, Spencer H, Jang, Jessica C, Odegaard, Justin I, Nair, Meera G. 2016. Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection. In Infection and immunity, 84, 1100-1111. doi:10.1128/IAI.01479-15. https://pubmed.ncbi.nlm.nih.gov/26831469/

4. Di Rosa, Michelino, Di Cataldo, Antonio, Broggi, Giuseppe, Raciti, Giuseppina, Li Volti, Giovanni. 2023. Resistin-like beta reduction is associated to low survival rate and is downregulated by adjuvant therapy in colorectal cancer patients. In Scientific reports, 13, 1490. doi:10.1038/s41598-023-28450-1. https://pubmed.ncbi.nlm.nih.gov/36707698/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest