Ifi30, also known as gamma-interferon-inducible lysosomal thiol reductase, is a crucial enzyme. It mainly exists in immune cells and functions in reducing protein disulfide bonds in endocytosis-mediated protein degradation. It is involved in antigen presentation and immune regulation, playing a role in pathways such as peptide antigen binding, cytokine binding, and MHC class II presentation [1,2]. It also has significance in processes like angiogenesis [3].

In breast cancer, high Ifi30 expression is associated with poor prognosis, and its knockdown reduces PD-L1 expression and inhibits breast cancer cell proliferation, migration, and invasion [1]. In glioma, high Ifi30 expression indicates malignancy and poor outcomes, and is an independent prognostic marker. It is also related to immune cell infiltration and immunosuppressive phenotypes [2,4]. In zebrafish, Ifi30 knockdown impairs caudal vein plexus formation, suggesting its role in sprouting angiogenesis [3].

In conclusion, Ifi30 is essential for immune regulation, antigen presentation, and angiogenesis. Studies using knockdown models in different organisms like zebrafish and in vitro cell models in human cancers such as breast cancer and glioma have revealed its role in disease-related processes. These findings provide potential targets for treating breast cancer and glioma [1-4].

References:

1. Li, Lei, Fei, Yinjiao, Dong, Tianfu, Liang, Mingxing, Tang, Jinhai. 2024. IFI30 as a key regulator of PDL1 immunotherapy prognosis in breast cancer. In International immunopharmacology, 133, 112093. doi:10.1016/j.intimp.2024.112093. https://pubmed.ncbi.nlm.nih.gov/38669947/

2. Liu, Xiu, Song, Chunyan, Yang, Shoubo, Chen, Feng, Li, Wenbin. 2020. IFI30 expression is an independent unfavourable prognostic factor in glioma. In Journal of cellular and molecular medicine, 24, 12433-12443. doi:10.1111/jcmm.15758. https://pubmed.ncbi.nlm.nih.gov/32969157/

3. Wang, Xiaoning, Ge, Xiaojuan, Qin, Yinyin, Liu, Dong, Chen, Changsheng. 2022. Ifi30 Is Required for Sprouting Angiogenesis During Caudal Vein Plexus Formation in Zebrafish. In Frontiers in physiology, 13, 919579. doi:10.3389/fphys.2022.919579. https://pubmed.ncbi.nlm.nih.gov/35910561/

4. Jiang, Wei, Zheng, Feifei, Yao, Taotao, Zheng, Wenjie, Yao, Ninghua. . IFI30 as a prognostic biomarker and correlation with immune infiltrates in glioma. In Annals of translational medicine, 9, 1686. doi:10.21037/atm-21-5569. https://pubmed.ncbi.nlm.nih.gov/34988195/