C57BL/6JCya-Gdaem1/Cya
Common Name
Gda-KO
Product ID
S-KO-16299
Backgroud
C57BL/6JCya
Strain ID
KOCMP-14544-Gda-B6J-VB
When using this mouse strain in a publication, please cite “Gda-KO Mouse (Catalog S-KO-16299) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Gda-KO
Strain ID
KOCMP-14544-Gda-B6J-VB
Gene Name
Product ID
S-KO-16299
Gene Alias
GAH
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 19
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000087600
NCBI RefSeq
NM_010266
Target Region
Exon 3
Size of Effective Region
~0.2 kb
Overview of Gene Research
Gda, also known as Glycodelin-A, is a glycoprotein proposed as a potential biomarker of endometrial function. It is synthesized by endometrial epithelial and stromal cells. Gda is involved in embryo implantation and has different glycosylated glycoforms expressed in each phase of the menstrual cycle [1]. It may play a role in maintaining endometrial receptivity, which is crucial for a successful pregnancy.
In women with endometriosis, the expression profile of Gda in the endometrium is altered. There is a significant increase in Gda protein expression with a different glycoforms profile during the secretory phase in endometriotic eutopic endometrium, and its protein localization is also different compared to women with proven fertility [1]. In cases of recurrent and spontaneous miscarriage, the protein level of Gda in the decidual stroma is significantly decreased compared to healthy pregnancies, and it shows a negative correlation with Pregnancy Zone Protein (PZP) in the decidual stromal tissue of recurrent abortion [2].
In conclusion, Gda is a complex glycoprotein with a role in endometrial function and embryo implantation. Its dysregulation in conditions like endometriosis and miscarriage indicates its importance in maintaining a healthy pregnancy environment. Understanding Gda through these observations provides insights into the mechanisms underlying endometrial-related pathologies and pregnancy-related disorders.
References:
1. Focarelli, Riccardo, Luddi, Alice, De Leo, Vincenzo, Petraglia, Felice, Piomboni, Paola. 2017. Dysregulation of GdA Expression in Endometrium of Women With Endometriosis: Implication for Endometrial Receptivity. In Reproductive sciences (Thousand Oaks, Calif.), 25, 579-586. doi:10.1177/1933719117718276. https://pubmed.ncbi.nlm.nih.gov/28683601/
2. Löb, Sanja, Vattai, Aurelia, Kuhn, Christina, Jeschke, Udo, Vilsmaier, Theresa. 2020. Pregnancy Zone Protein (PZP) is significantly upregulated in the decidua of recurrent and spontaneous miscarriage and negatively correlated to Glycodelin A (GdA). In Journal of reproductive immunology, 143, 103267. doi:10.1016/j.jri.2020.103267. https://pubmed.ncbi.nlm.nih.gov/33388716/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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