C57BL/6JCya-Parvbem1/Cya
Common Name
Parvb-KO
Product ID
S-KO-16317
Backgroud
C57BL/6JCya
Strain ID
KOCMP-170736-Parvb-B6J-VB
Status
When using this mouse strain in a publication, please cite “Parvb-KO Mouse (Catalog S-KO-16317) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Parvb-KO
Strain ID
KOCMP-170736-Parvb-B6J-VB
Gene Name
Product ID
S-KO-16317
Gene Alias
D15Gsk1, affixin
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 15
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000023072
NCBI RefSeq
NM_133167.3
Target Region
Exon 4
Size of Effective Region
~0.1 kb
Overview of Gene Research
Parvb, also known as beta-parvin, is an actin-binding and focal adhesion protein. It is involved in linking integrins and associated proteins with intracellular pathways regulating actin cytoskeletal dynamics and cell survival [3]. The ILK-β-parvin pathway, in which Parvb is a part, can enhance cell motility [2].
In a PARVB cKO mouse model where the Parvb gene was deleted from proximal tubular epithelial cells, depletion of Parvb significantly attenuated cisplatin-induced renal tubular injury, including cell death and inflammation. Mechanistically, Parvb associates with TAK1, and its depletion promotes TAK1 degradation, inhibits TAK1 downstream signaling, and alleviates cisplatin-induced tubular cell damage [1]. In addition, in Fscn2 knockout mice, upregulation of Parvb contributed to cochlear cell death by inhibiting the ILK-AKT pathway [4].
In conclusion, Parvb plays a crucial role in regulating cell survival and motility through its involvement in various pathways. The study of Parvb using gene knockout mouse models has revealed its significance in diseases such as cisplatin-induced kidney damage and genetic hearing loss, providing potential therapeutic targets for these conditions.
References:
1. Yang, Aihua, Ding, Yanyan, Guo, Chen, Wu, Chuanyue, Sun, Ying. 2024. PARVB deficiency alleviates cisplatin-induced tubular injury by inhibiting TAK1 signaling. In Cellular and molecular life sciences : CMLS, 81, 385. doi:10.1007/s00018-024-05422-w. https://pubmed.ncbi.nlm.nih.gov/39235496/
2. Yang, Linbin, Liu, Qiang, Zhang, Xiaoqian, Su, Shicheng, Song, Erwei. 2020. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. In Nature, 583, 133-138. doi:10.1038/s41586-020-2394-6. https://pubmed.ncbi.nlm.nih.gov/32528174/
3. Sepulveda, J L, Wu, C. . The parvins. In Cellular and molecular life sciences : CMLS, 63, 25-35. doi:. https://pubmed.ncbi.nlm.nih.gov/16314921/
4. Liu, Rongrong, Shang, Wenjing, Liu, Yingying, Song, Xicheng, Han, Fengchan. 2024. Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice. In Cell death discovery, 10, 89. doi:10.1038/s41420-024-01851-5. https://pubmed.ncbi.nlm.nih.gov/38374196/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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