Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Fam162aem1/Cya
Common Name:
Fam162a-KO
Product ID:
S-KO-16324
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Fam162a-KO
Strain ID
KOCMP-70186-Fam162a-B6J-VB
Gene Name
Fam162a
Product ID
S-KO-16324
Gene Alias
2310056P07Rik; HGTD-P
Background
C57BL/6JCya
NCBI ID
70186
Modification
Conventional knockout
Chromosome
16
Phenotype
MGI:1917436
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fam162aem1/Cya mice (Catalog S-KO-16324) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000004057
NCBI RefSeq
NM_027342
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Fam162a, whose specific function is yet to be fully elucidated, has been associated with multiple biological processes. It has been linked to hypoxia-related pathways, lactate metabolism, and glycolysis. These pathways are crucial in various physiological and pathological conditions, such as tumor development, energy metabolism, and response to stress [1,3,4].

Fam162a has been identified in several disease-related gene signatures. In osteosarcoma, it is part of an 8-gene signature related to hypoxia and lactate metabolism, which can predict prognosis, classify "cold" and "hot" tumors, and estimate immunotherapy response [1]. In IDH-mutant glioma, a hypoxia-related survival score including Fam162a can predict patient survival independent of known prognostic factors [3]. In coronary artery disease, it is one of the 4 hub hypoxia-related genes, and is mainly enriched in immune-related biological processes [2]. In colon cancer, it is part of a 13-gene glycolysis-related prognostic prediction model [4]. In addition, it may be related to neuronal apoptosis in chronic cerebral ischemia, as Foxh1 transcriptionally promotes its expression [5].

In conclusion, Fam162a appears to play a significant role in multiple disease conditions, particularly those related to hypoxia, metabolism, and immunity. Findings from various studies suggest its potential as a biomarker or therapeutic target in diseases such as osteosarcoma, glioma, coronary artery disease, and colon cancer. Research on Fam162a provides insights into the underlying mechanisms of these diseases and may offer new directions for treatment strategies.

References:

1. Wang, Yizhuo, Wang, Xin, Liu, Yang, Zheng, Yufu, Qi, Quan. 2024. A novel hypoxia- and lactate metabolism-related prognostic signature to characterize the immune landscape and predict immunotherapy response in osteosarcoma. In Frontiers in immunology, 15, 1467052. doi:10.3389/fimmu.2024.1467052. https://pubmed.ncbi.nlm.nih.gov/39569192/

2. Jin, Yuqing, Ren, Weiyan, Liu, Jiayi, Hou, Lianguo, Yang, Lei. 2023. Identification and validation of potential hypoxia-related genes associated with coronary artery disease. In Frontiers in physiology, 14, 1181510. doi:10.3389/fphys.2023.1181510. https://pubmed.ncbi.nlm.nih.gov/37637145/

3. Dao Trong, Philip, Rösch, Saskia, Mairbäurl, Heimo, Herold-Mende, Christel, Warta, Rolf. 2018. Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma. In International journal of molecular sciences, 19, . doi:10.3390/ijms19102903. https://pubmed.ncbi.nlm.nih.gov/30257451/

4. Liu, Gang, Wu, Xiaoyang, Chen, Jian. 2022. Identification and validation of a glycolysis-related gene signature for depicting clinical characteristics and its relationship with tumor immunity in patients with colon cancer. In Aging, 14, 8700-8718. doi:10.18632/aging.204226. https://pubmed.ncbi.nlm.nih.gov/35963622/

5. Yang, Jin, Liu, Xiaobai, Zhao, Yubo, Cui, Zheng, Liu, Yunhui. 2023. Mechanism of Dcp2/RNCR3/Dkc1/Snora62 axis regulating neuronal apoptosis in chronic cerebral ischemia. In Cell biology and toxicology, 39, 2881-2898. doi:10.1007/s10565-023-09807-8. https://pubmed.ncbi.nlm.nih.gov/37097350/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest