C57BL/6JCya-Mrps21em1/Cya
Common Name:
Mrps21-KO
Product ID:
S-KO-16479
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mrps21-KO
Strain ID
KOCMP-66292-Mrps21-B6J-VA
Gene Name
Product ID
S-KO-16479
Gene Alias
1810031B19Rik; S21mt
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mrps21em1/Cya mice (Catalog S-KO-16479) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000067298
NCBI RefSeq
NM_001355759
Target Region
Exon 3
Size of Effective Region
~1.6 kb
Detailed Document
Overview of Gene Research
Mrps21, Mitochondrial Ribosomal Protein S21, is an essential component for the structural and functional integrity of the mitoribosome complex [1]. Mitoribosomes are crucial for mitochondrial protein synthesis, which is involved in various cellular processes such as energy production through oxidative phosphorylation [1].
In a study on hepatocellular carcinoma (HCC), MRPS21 was among 14 MRP genes significantly upregulated in tumor samples compared to normal samples, suggesting its potential as a diagnostic marker for HCC [2]. In the context of spontaneous coronary artery dissection (SCAD), a SNP (rs580060) in the 3'-UTR of MRPS21 was an A-to-I modification SNP, and a genome-wide significant SNP (rs3818978) in the 5'-UTR was related to m6A modification, indicating the involvement of RNA modifications of MRPS21 in SCAD [3]. Also, a region containing MRPS21-PRPF3 showed suggestive evidence of association with the progression from islet autoimmunity to type 1 diabetes [4]. In equine skeletal muscle, MRPS21 expression increased following a ten-month exercise training period, suggesting its role in muscle-related functional changes [5].
In summary, Mrps21 is vital for mitoribosome function. Its abnormal regulation, whether through differential expression in HCC or RNA modifications in SCAD, and its association with the progression of islet autoimmunity to type 1 diabetes, indicates its importance in multiple disease conditions. The increase in its expression with exercise training in horses also points to its role in muscle-related physiological adaptations. These findings from various studies help in understanding the diverse functions of Mrps21 in different biological and disease contexts.
References:
1. Cheong, Agnes, Lingutla, Ranjana, Mager, Jesse. 2020. Expression analysis of mammalian mitochondrial ribosomal protein genes. In Gene expression patterns : GEP, 38, 119147. doi:10.1016/j.gep.2020.119147. https://pubmed.ncbi.nlm.nih.gov/32987154/
2. Zhao, Jin-Wei, Zhao, Wei-Yi, Cui, Xin-Hua, Shi, Jia-Cheng, Yu, Lu. 2023. The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity. In Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 26, 496-514. doi:10.1007/s12094-023-03269-4. https://pubmed.ncbi.nlm.nih.gov/37407805/
3. Chai, Tianci, Tian, Mengyue, Yang, Xiaojie, Lin, Xinjian, Chen, Liangwan. 2021. Genome-Wide Identification of RNA Modifications for Spontaneous Coronary Aortic Dissection. In Frontiers in genetics, 12, 696562. doi:10.3389/fgene.2021.696562. https://pubmed.ncbi.nlm.nih.gov/34276799/
4. Onengut-Gumuscu, Suna, Paila, Umadevi, Chen, Wei-Min, Rewers, Marian J, Rich, Stephen S. 2020. Novel genetic risk factors influence progression of islet autoimmunity to type 1 diabetes. In Scientific reports, 10, 19193. doi:10.1038/s41598-020-75690-6. https://pubmed.ncbi.nlm.nih.gov/33154504/
5. McGivney, Beatrice A, McGettigan, Paul A, Browne, John A, Katz, Lisa M, Hill, Emmeline W. 2010. Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training. In BMC genomics, 11, 398. doi:10.1186/1471-2164-11-398. https://pubmed.ncbi.nlm.nih.gov/20573200/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen