Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Dcp1aem1/Cya
Common Name:
Dcp1a-KO
Product ID:
S-KO-16582
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Dcp1a-KO
Strain ID
KOCMP-75901-Dcp1a-B6J-VB
Gene Name
Dcp1a
Product ID
S-KO-16582
Gene Alias
1110066A22Rik; 4930568L04Rik; D14Ertd817e; Mitc1; SMIF
Background
C57BL/6JCya
NCBI ID
75901
Modification
Conventional knockout
Chromosome
14
Phenotype
MGI:1923151
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dcp1aem1/Cya mice (Catalog S-KO-16582) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022535
NCBI RefSeq
NM_133761.3
Target Region
Exon 4~5
Size of Effective Region
~3.3 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Dcp1a, the mRNA decapping factor, is crucial in posttranscriptional regulation of gene expression in eukaryotes. It is involved in mRNA cap removal before degradation, a key step in controlling the fate of mRNAs, and is associated with P-bodies, cytoplasmic foci related to mRNA degradation and translational repression [2,7].

Genetic models have provided significant insights into Dcp1a's function. In mice, Dcp1a-deficient embryos generated using the Nuclease technology system exhibit embryonic lethality around embryonic day 10.5 (E10.5), along with growth retardation and cardiac developmental defects, indicating its essential role in embryonic growth [2]. In mouse embryonic stem cells (ESCs), DCP1A, phosphorylated by MEK, is required for self-renewal and differentiation, with its dephosphorylation promoting P-body formation and RNA storage [3]. In muscle stem cells, Dcp1a knockdown leads to increased cell proliferation during the activation stage, while knockdown of both Dcp1a and Fmrp compromises differentiation, suggesting its role in regulating muscle stem cell quiescence and activation [6]. In the context of viral infection, porcine deltacoronavirus nsp5 cleaves DCP1A, reducing its antiviral activity, and this may be a common immune-evasion mechanism among coronaviruses [4]. In cancer, high DCP1A expression in hepatocellular carcinoma and gastric cancer is associated with poor prognosis, advanced tumor stage, and chemotherapy resistance [1,5].

In summary, Dcp1a is essential for embryonic growth, regulation of stem cell self-renewal and differentiation, muscle stem cell function, and antiviral defense. Its dysregulation is implicated in cancer development and progression. Mouse models, including gene knockout models, have been instrumental in revealing these functions, providing valuable insights into normal biological processes and disease mechanisms related to Dcp1a.

References:

1. Wu, Hao, Zhang, Jinrui, Bai, Yi, Zhang, Yamin, Shen, Zhongyang. 2021. DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma. In Aging, 13, 23020-23035. doi:10.18632/aging.203593. https://pubmed.ncbi.nlm.nih.gov/34609335/

2. Ibayashi, Megumi, Aizawa, Ryutaro, Tsukamoto, Satoshi. 2021. mRNA decapping factor Dcp1a is essential for embryonic growth in mice. In Biochemical and biophysical research communications, 555, 128-133. doi:10.1016/j.bbrc.2021.03.117. https://pubmed.ncbi.nlm.nih.gov/33813271/

3. Yu, Jiayu, Zhao, Nannan, Wang, Yuying, Zhang, Kai, Chen, Lingyi. 2024. DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells. In Cell reports, 43, 115058. doi:10.1016/j.celrep.2024.115058. https://pubmed.ncbi.nlm.nih.gov/39671288/

4. Zhu, Xinyu, Chen, Jiyao, Tian, Liyuan, Fang, Liurong, Xiao, Shaobo. 2020. Porcine Deltacoronavirus nsp5 Cleaves DCP1A To Decrease Its Antiviral Activity. In Journal of virology, 94, . doi:10.1128/JVI.02162-19. https://pubmed.ncbi.nlm.nih.gov/32461317/

5. Ruan, Tuo, Zhang, Yazhi, Liu, Weizhen, Tao, Kaixiong, Wu, Chuanqing. 2020. Expression of DCP1a in gastric cancer and its biological function and mechanism in chemotherapy resistance in gastric cancer cells. In Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 52, 1351-1358. doi:10.1016/j.dld.2020.06.031. https://pubmed.ncbi.nlm.nih.gov/32646734/

6. Roy, Nainita, Sundar, Swetha, Pillai, Malini, Zammit, Peter S, Dhawan, Jyotsna. 2021. mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation. In Skeletal muscle, 11, 18. doi:10.1186/s13395-021-00270-9. https://pubmed.ncbi.nlm.nih.gov/34238354/

7. Blumenthal, Jacob, Behar, Leah, Elliott, Evan, Ginzburg, Irith. 2008. Dcp1a phosphorylation along neuronal development and stress. In FEBS letters, 583, 197-201. doi:10.1016/j.febslet.2008.12.002. https://pubmed.ncbi.nlm.nih.gov/19084008/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest