C57BL/6NCya-Iqcf5em1/Cya
Common Name
Iqcf5-KO
Product ID
S-KO-16589
Backgroud
C57BL/6NCya
Strain ID
KOCMP-75470-Iqcf5-B6N-VA
When using this mouse strain in a publication, please cite “Iqcf5-KO Mouse (Catalog S-KO-16589) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Iqcf5-KO
Strain ID
KOCMP-75470-Iqcf5-B6N-VA
Gene Name
Product ID
S-KO-16589
Gene Alias
1700007L12Rik
Background
C57BL/6NCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000085113
NCBI RefSeq
NM_029300
Target Region
Exon 1~2
Size of Effective Region
~2.8kb
Overview of Gene Research
Iqcf5, a member of the IQ motif-containing family, is likely involved in cellular functions related to the domains conferred by its IQ motifs, which often interact with calmodulin-like proteins. However, its exact function, associated pathways, and overall biological importance are yet to be fully elucidated, but genetic models could be valuable for in-depth functional studies.
In a study comparing prostate cancer genomics among different ancestries [1], the somatic amplification of Iqcf5 was more frequent in prostate tumors arising in men of Middle Eastern (ME) ancestry compared to European (EUR) ancestry (two-sided proportion test; Q < 0.05). This finding suggests that Iqcf5 may play a role in the genomic landscape of prostate cancer in ME populations.
In conclusion, while the precise biological functions of Iqcf5 are still being explored, its differential amplification in ME prostate cancer tumors indicates a potential role in this disease area. Further research using gene knockout (KO) or conditional knockout (CKO) mouse models could help uncover its exact functions and how its amplification contributes to prostate cancer in ME-ancestry men. [1]
References:
1. Albawardi, Alia, Livingstone, Julie, Almarzooqi, Saeeda, Boutros, Paul C, Bismar, Tarek A. 2021. Copy Number Profiles of Prostate Cancer in Men of Middle Eastern Ancestry. In Cancers, 13, . doi:10.3390/cancers13102363. https://pubmed.ncbi.nlm.nih.gov/34068856/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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