Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Tbataem1/Cya
Common Name:
Tbata-KO
Product ID:
S-KO-16634
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Tbata-KO
Strain ID
KOCMP-65971-Tbata-B6J-VB
Gene Name
Tbata
Product ID
S-KO-16634
Gene Alias
1700021K02Rik; Spatial; Titest
Background
C57BL/6JCya
NCBI ID
65971
Modification
Conventional knockout
Chromosome
10
Phenotype
MGI:1923820
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Tbataem1/Cya mice (Catalog S-KO-16634) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000035894
NCBI RefSeq
NM_001017433
Target Region
Exon 4~5
Size of Effective Region
~1.1 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Tbata, also known as SPATIAL, is a gene that plays crucial roles in multiple biological processes. It is expressed in thymic stromal cells, brain neurons, and testis germ cells. In thymic stromal cells, Tbata regulates thymic epithelial cell (TEC) proliferation and thymus size by interacting with the enzyme Uba3 and inhibiting the Nedd8 pathway [1]. In neurons, it is involved in neurite outgrowth and dendrite patterning, with its expression being increased by Nerve Growth Factor (NGF) and its localization to dendrites relying on the kinesin motor Kif17 [2].

In gene-related studies, thymi from aged Tbata-deficient mice are larger and contain more dividing TECs compared to wild-type littermate controls. Also, thymic reconstitution after bone marrow transplantation occurs more rapidly in Rag2(-/-)Tbata(-/-) mice than in Rag2(-/-)Tbata(+/+) littermate controls, suggesting its role in thymus function regulation via stromal cell proliferation [1]. In zebrafish, knockdown of Tbata orthologs shows its indispensability for enteric nervous system (ENS) development, and this was confirmed by CRISPR knockout, indicating its role in ENS-related processes [3].

In conclusion, Tbata is essential for thymus function through its regulation of stromal cell proliferation and also plays important roles in neuronal development and ENS development. The use of gene-knockout mouse models and zebrafish models has provided significant insights into Tbata's functions in these biological processes.

References:

1. Flomerfelt, Francis A, El Kassar, Nahed, Gurunathan, Chandra, Schwartz, Ronald H, Gress, Ronald E. 2010. Tbata modulates thymic stromal cell proliferation and thymus function. In The Journal of experimental medicine, 207, 2521-32. doi:10.1084/jem.20092759. https://pubmed.ncbi.nlm.nih.gov/20937703/

2. Yammine, Miriam, Saade, Murielle, Chauvet, Sophie, Nguyen, Catherine. 2013. Spatial gene's (Tbata) implication in neurite outgrowth and dendrite patterning in hippocampal neurons. In Molecular and cellular neurosciences, 59, 1-9. doi:10.1016/j.mcn.2013.12.007. https://pubmed.ncbi.nlm.nih.gov/24361585/

3. Gui, Hongsheng, Schriemer, Duco, Cheng, William W, Garcia-Barceló, Maria-Mercè, Hofstra, Robert M W. 2017. Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes. In Genome biology, 18, 48. doi:10.1186/s13059-017-1174-6. https://pubmed.ncbi.nlm.nih.gov/28274275/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest