C57BL/6JCya-Zfp39em1/Cya
Common Name:
Zfp39-KO
Product ID:
S-KO-16649
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zfp39-KO
Strain ID
KOCMP-22698-Zfp39-B6J-VB
Gene Name
Product ID
S-KO-16649
Gene Alias
CTfin33; Zfp-39
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
11
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zfp39em1/Cya mice (Catalog S-KO-16649) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000102703
NCBI RefSeq
NM_011758
Target Region
Exon 4~5
Size of Effective Region
~4.5 kb
Detailed Document
Overview of Gene Research
Zfp39, whose full function and common aliases are not clearly elaborated in the given references, has been associated with maintaining embryonic stem (ES) cell pluripotency and self-renewal. In murine ES cells, through signed weighted gene co-expression network analysis (WGCNA), it was identified, along with other genes, as having important roles in these processes. This finding indicates its potential involvement in pathways related to ES cell regulation [1].
In an experiment examining candidate imprinted genes on mouse chromosome 11, Zfp39 was among the genes tested. However, no evidence of imprinting in the brain was found for Zfp39, though strain-biased expression was observed for some other genes in the study [2].
In conclusion, Zfp39 seems to be important for maintaining ES cell pluripotency and self-renewal, as shown through network analysis in murine ES cells. Although no imprinting was detected in the brain in the chromosome 11 gene-testing experiment, the study of Zfp39 using mouse models contributes to understanding ES cell biology and potentially the complexity of gene imprinting and expression regulation.
References:
1. Mason, Mike J, Fan, Guoping, Plath, Kathrin, Zhou, Qing, Horvath, Steve. 2009. Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. In BMC genomics, 10, 327. doi:10.1186/1471-2164-10-327. https://pubmed.ncbi.nlm.nih.gov/19619308/
2. Tuskan, Robert G, Tsang, Shirley, Sun, Zhonghe, Munroe, David J, Reilly, Karlyne M. 2007. Real-time PCR analysis of candidate imprinted genes on mouse chromosome 11 shows balanced expression from the maternal and paternal chromosomes and strain-specific variation in expression levels. In Epigenetics, 3, 43-50. doi:. https://pubmed.ncbi.nlm.nih.gov/18188004/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen