C57BL/6JCya-Dtnbp1em1/Cya
Common Name:
Dtnbp1-KO
Product ID:
S-KO-16789
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Dtnbp1-KO
Strain ID
KOCMP-94245-Dtnbp1-B6J-VB
Gene Name
Product ID
S-KO-16789
Gene Alias
5430437B18Rik; Bloc1s8; dysbindin; sdy
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Dtnbp1em1/Cya mice (Catalog S-KO-16789) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000072329
NCBI RefSeq
NM_025772
Target Region
Exon 4
Size of Effective Region
~0.1 kb
Detailed Document
Overview of Gene Research
Dtnbp1, also known as dystrobrevin binding protein 1 or dysbindin, is a gene that has emerged as a potential susceptibility gene for schizophrenia [1]. It is involved in neurotransmission regulation, especially of dopamine and glutamate, and is associated with neurodevelopment [2]. Additionally, it may be related to pathways leading to multiple psychiatric phenotypes [2].
Over recent years, Dtnbp1 has been extensively studied in relation to schizophrenia. Genetic association studies have provided support for its role as a schizophrenia-susceptibility gene, although the actual susceptibility variants remain to be identified [1]. Variants of Dtnbp1 have been associated with hallucinations in schizophrenia, such as specific auditory and visual hallucinations, which is consistent with its activity in relevant processing regions and its role in regulating glutamate and dopamine activity [2]. In schizophrenic patients, Dtnbp1 gene variants have been shown to modulate prefrontal brain function, potentially through glutamatergic transmission, providing support for the glutamate hypothesis of schizophrenia [3]. The gene has also been investigated in relation to psychotic depression, with certain SNPs and haplotypes found to be associated with the risk of psychotic depression, suggesting a possible neurobiological link between affective disorders and schizophrenia [4].
In conclusion, Dtnbp1 plays a significant role in neurobiology, particularly in relation to psychiatric disorders such as schizophrenia and psychotic depression. Studies on Dtnbp1 have provided insights into the genetic and neurophysiological mechanisms underlying these diseases, highlighting its importance in understanding the pathophysiology of mental illnesses.
References:
1. Williams, Nigel M, O'Donovan, Michael C, Owen, Michael J. 2005. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia? In Schizophrenia bulletin, 31, 800-5. doi:. https://pubmed.ncbi.nlm.nih.gov/16166606/
2. Cheah, S-Y, Lawford, B R, Young, R M, Morris, C P, Voisey, J. 2015. Dysbindin (DTNBP1) variants are associated with hallucinations in schizophrenia. In European psychiatry : the journal of the Association of European Psychiatrists, 30, 486-91. doi:10.1016/j.eurpsy.2015.01.008. https://pubmed.ncbi.nlm.nih.gov/25697573/
3. Fallgatter, A J, Ehlis, A-C, Herrmann, M J, Freitag, C M, Deckert, J. 2010. DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias. In Genes, brain, and behavior, 9, 489-97. doi:10.1111/j.1601-183X.2010.00574.x. https://pubmed.ncbi.nlm.nih.gov/20180862/
4. Domschke, Katharina, Lawford, Bruce, Young, Ross, Arolt, Volker, Baune, Bernhard T. 2010. Dysbindin (DTNBP1)--a role in psychotic depression? In Journal of psychiatric research, 45, 588-95. doi:10.1016/j.jpsychires.2010.09.014. https://pubmed.ncbi.nlm.nih.gov/20951386/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen