C57BL/6JCya-Avpr1aem1/Cya
Common Name
Avpr1a-KO
Product ID
S-KO-16888
Backgroud
C57BL/6JCya
Strain ID
KOCMP-54140-Avpr1a-B6J-VB
When using this mouse strain in a publication, please cite “Avpr1a-KO Mouse (Catalog S-KO-16888) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Avpr1a-KO
Strain ID
KOCMP-54140-Avpr1a-B6J-VB
Gene Name
Product ID
S-KO-16888
Gene Alias
AVPR, Avpr1, V1a, V1aR
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 10
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000020323
NCBI RefSeq
NM_016847.2
Target Region
Exon 1
Size of Effective Region
~2.3 kb
Overview of Gene Research
Avpr1a, the arginine vasopressin receptor 1A gene, encodes a receptor that interacts with arginine vasopressin hormone. It is involved in physiological stress regulation, blood pressure control, and child development [1]. The neuropeptide arginine vasopressin (AVP), which binds to AVPR1A, plays significant roles in maintaining homeostasis and regulating social behavior [2].
In a mouse model, AVPR1A ligand binding was observed in sensory tissues of the head, bone, spinal cord, adrenal cortex, and uro-anogenital region of neonatal wild-type mice, suggesting roles for AVP in modulating neonatal peripheral physiology and development [2]. In female mice, loss-of-function studies demonstrated that AVPR1A signaling in the central nucleus of the amygdala (CeA) is required for the effects of chronic social isolation stress on anxiety-related behaviors, highlighting its role in social stress-related responses [3].
In conclusion, Avpr1a is crucial for multiple biological processes, including neonatal development and social behavior-related stress responses. The gene knockout or loss-of-function mouse models have been instrumental in revealing its role in these areas, potentially providing insights into related human conditions such as anxiety-related disorders [3].
References:
1. Nidey, Nichole, Bowers, Katherine, Ding, Lili, Mahabee-Gittens, E Melinda, Folger, Alonzo T. 2023. Neonatal AVPR1a Methylation and In-Utero Exposure to Maternal Smoking. In Toxics, 11, . doi:10.3390/toxics11100855. https://pubmed.ncbi.nlm.nih.gov/37888705/
2. Day, Katherine R, Coleman, Alexis, Greenwood, Maria A, Hammock, Elizabeth A D. 2020. AVPR1A distribution in the whole C57BL/6J mouse neonate. In Scientific reports, 10, 14512. doi:10.1038/s41598-020-71392-1. https://pubmed.ncbi.nlm.nih.gov/32884025/
3. François, Marie, Delgado, Isabella Canal, Lafond, Alexandre, Dölen, Gül, Zeltser, Lori M. 2023. Amygdala AVPR1A mediates susceptibility to chronic social isolation in females. In bioRxiv : the preprint server for biology, , . doi:10.1101/2023.02.15.528679. https://pubmed.ncbi.nlm.nih.gov/36824966/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.