C57BL/6JCya-Slc16a1em1/Cya
Common Name
Slc16a1-KO
Product ID
S-KO-16927
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20501-Slc16a1-B6J-VB
Status
When using this mouse strain in a publication, please cite “Slc16a1-KO Mouse (Catalog S-KO-16927) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Slc16a1-KO
Strain ID
KOCMP-20501-Slc16a1-B6J-VB
Gene Name
Product ID
S-KO-16927
Gene Alias
Mct1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 3
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000046212
NCBI RefSeq
NM_009196
Target Region
Exon 3~4
Size of Effective Region
~3.3 kb
Overview of Gene Research
Slc16a1, also known as monocarboxylate transporter 1 (MCT1), is a proton-dependent transporter that functions as a lactate transporter [2]. It is involved in multiple biological processes by mediating the transmembrane transport of monocarboxylates, which impacts cellular metabolism and communication. This gene is also a significant determinant in the absorption, renal reabsorption, and brain and tissue uptake of substances like gamma-hydroxybutyrate (GHB) [2].
In the context of hepatocellular carcinoma (HCC), HCC exosomal SLC16A1-AS1 (antisense RNA of SLC16A1) enhances SLC16A1 mRNA stabilization in macrophages. As a lactate transporter, SLC16A1 then accelerates lactate influx, activating the c-Raf/ERK signaling pathway to induce M2 polarization of macrophages. This reciprocal signaling between HCC cells and M2 macrophages promotes the proliferation, invasion, and glycolysis of HCC cells [1].
In summary, Slc16a1 is a crucial lactate transporter involved in important biological processes and has implications in cancer progression, especially in hepatocellular carcinoma. Studies related to Slc16a1, such as those in the HCC context, help us understand its role in disease-related cellular communication and metabolic regulation, potentially providing new targets for cancer treatment.
References:
1. Hu, Yuhang, Li, Yang, Xiong, Hewei, Lv, Guozheng, Zhao, Gang. 2024. Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression. In International journal of biological sciences, 20, 4341-4363. doi:10.7150/ijbs.94440. https://pubmed.ncbi.nlm.nih.gov/39247822/
2. Felmlee, Melanie A, Morse, Bridget L, Morris, Marilyn E. 2021. γ-Hydroxybutyric Acid: Pharmacokinetics, Pharmacodynamics, and Toxicology. In The AAPS journal, 23, 22. doi:10.1208/s12248-020-00543-z. https://pubmed.ncbi.nlm.nih.gov/33417072/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.