C57BL/6JCya-Ddoem1/Cya
Common Name:
Ddo-KO
Product ID:
S-KO-16960
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ddo-KO
Strain ID
KOCMP-70503-Ddo-B6J-VB
Gene Name
Product ID
S-KO-16960
Gene Alias
5330420D20Rik; 5730402C02Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ddoem1/Cya mice (Catalog S-KO-16960) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000019977
NCBI RefSeq
NM_027442.5
Target Region
Exon 3
Size of Effective Region
~2.1 kb
Detailed Document
Overview of Gene Research
Ddo, whose full name is D-aspartate oxidase, is an enzyme-encoding gene involved in the peroxisome-related pathways [1]. Peroxisomes are associated with lipid metabolism and regulation of reactive oxygen species, highlighting the potential importance of Ddo in maintaining cellular homeostasis.
In a study on non-small cell lung cancer (NSCLC), genetic variants in Ddo were investigated. The SNP rs9384742 in Ddo was significantly associated with NSCLC overall survival. The minor allele of rs9384742 was associated with decreased Ddo messenger RNA (mRNA) expression levels, and Ddo expression was also decreased in NSCLC tumor tissue. This indicates that Ddo may play a role in the development and progression of NSCLC [1].
In conclusion, Ddo's involvement in peroxisome-related pathways suggests its importance in cellular processes related to lipid metabolism and oxidative stress regulation. The discovery of its genetic variants associated with NSCLC survival provides insights into the role of Ddo in this cancer, highlighting the potential of Ddo as a biomarker or therapeutic target in NSCLC research [1].
References:
1. Chen, Allan S, Liu, Hongliang, Wu, Yufeng, Christiani, David C, Wei, Qingyi. 2022. Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival. In Molecular carcinogenesis, 61, 619-628. doi:10.1002/mc.23400. https://pubmed.ncbi.nlm.nih.gov/35502931/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen