C57BL/6JCya-Il19em1/Cya
Common Name:
Il19-KO
Product ID:
S-KO-17039
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Il19-KO
Strain ID
KOCMP-329244-Il19-B6J-VA
Gene Name
Product ID
S-KO-17039
Gene Alias
--
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Il19em1/Cya mice (Catalog S-KO-17039) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000112465
NCBI RefSeq
NM_001009940
Target Region
Exon 4~6
Size of Effective Region
~3.9 kb
Detailed Document
Overview of Gene Research
Il19, a member of the IL-10 family of cytokines, is involved in diverse biological functions. It elicits host defense mechanisms, especially from epithelial cells during infections, and is essential for maintaining tissue epithelial layer integrity and homeostasis. It can promote innate immune responses and facilitate tissue-healing processes. The signaling of Il19 may be associated with the JAK1/STAT3 pathway [1,2].
In lung cancer, tumor cells can induce osteoclasts to secrete Il19, which then stimulates Il-20RB-expressing tumor cells via the JAK1/STAT3 signaling, promoting metastatic growth in bone, and blocking Il-20RB can suppress bone metastasis [2]. In atopic dermatitis, a novel Il19 + IGFL1 + keratinocyte subpopulation increases in lesions, which may disrupt the skin barrier, connect and magnify Th2 and Th17 inflammatory responses, and mediate skin pruritus [3]. DNA damage can enhance Il19 expression through JNK and cGAS-STING pathways, and Il19 is required for subsequent production of cytokines like IL-1, IL-6, and IL-8 [4].
In conclusion, Il19 is crucial for host defense, tissue homeostasis, and immune responses. Studies, such as those on lung cancer bone metastasis, atopic dermatitis, and DNA-damage-induced cytokine production, have revealed its role in disease-related biological processes. These findings contribute to understanding the functions of Il19 in disease development, potentially guiding future research and therapeutic strategies.
References:
1. Ouyang, Wenjun, Rutz, Sascha, Crellin, Natasha K, Valdez, Patricia A, Hymowitz, Sarah G. . Regulation and functions of the IL-10 family of cytokines in inflammation and disease. In Annual review of immunology, 29, 71-109. doi:10.1146/annurev-immunol-031210-101312. https://pubmed.ncbi.nlm.nih.gov/21166540/
2. He, Yunfei, Luo, Wenqian, Liu, Yingjie, Yao, Feng, Hu, Guohong. 2022. IL-20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer. In The Journal of clinical investigation, 132, . doi:10.1172/JCI157917. https://pubmed.ncbi.nlm.nih.gov/36006737/
3. Zhou, Jie, Liang, Gaopeng, Liu, Lu, Wang, Li, Song, Zhiqiang. 2023. Single-cell RNA-seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitis. In Journal of the European Academy of Dermatology and Venereology : JEADV, 37, 2336-2348. doi:10.1111/jdv.19256. https://pubmed.ncbi.nlm.nih.gov/37326015/
4. Small, Sara H, Tang, E Jessica, Ragland, Ryan L, Johnson, F Bradley, Brown, Eric J. 2021. Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage-induced cytokine production. In Science signaling, 14, eaba2611. doi:10.1126/scisignal.aba2611. https://pubmed.ncbi.nlm.nih.gov/34932373/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen