C57BL/6JCya-Embem1/Cya
Common Name
Emb-KO
Product ID
S-KO-17098
Backgroud
C57BL/6JCya
Strain ID
KOCMP-13723-Emb-B6J-VB
Status
When using this mouse strain in a publication, please cite “Emb-KO Mouse (Catalog S-KO-17098) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
The standard delivery applies for a guaranteed minimum of three heterozygous carriers. Breeding services for homozygous carriers and/or specified sex are available.
Basic Information
Strain Name
Emb-KO
Strain ID
KOCMP-13723-Emb-B6J-VB
Gene Name
Product ID
S-KO-17098
Gene Alias
Gp70
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 13
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000022242
NCBI RefSeq
NM_010330
Target Region
Exon 5
Size of Effective Region
~2.9 kb
Overview of Gene Research
Embigin (EMB) is a transmembrane glycoprotein. In glioblastoma multiforme (GBM), EMB is highly expressed and associated with poor prognosis. It drives GBM progression by upregulating epithelial-mesenchymal transition (EMT) and glycolysis, while maintaining glutathione (GSH) redox balance through inducing monocarboxylate transporter 4 (MCT4) and glutathione peroxidase 3 (GPX3) expression [1].
In maize, the EMB-7L gene encodes a chloroplast-localized P-type pentatricopeptide repeat (PPR) protein. It is required for embryogenesis and plant development, being involved in the RNA splicing of multiple chloroplast genes. Transcription of chloroplast protein-encoding genes and pre-mRNA intron splicing are affected in a tissue-dependent pattern in emb-7L mutants, with dramatic impacts on chloroplast structure, activity, and related metabolic product synthesis [2].
In conclusion, EMB has significant functions in both plant development and cancer progression. In plants like maize, it is crucial for embryogenesis and chloroplast-related processes. In GBM, EMB is an independent prognostic biomarker and a driver of tumor progression, highlighting its importance in understanding the mechanisms of GBM and potentially developing new treatment strategies.
References:
1. Cheng, Bo, Liu, Jing, Gao, Ling, Liu, Shangqi, Wu, Xiaojin. 2025. EMB-driven glioblastoma multiforme progression via the MCT4/GPX3 axis: therapeutic inhibition by Ganxintriol A. In Journal of translational medicine, 23, 272. doi:10.1186/s12967-025-06290-z. https://pubmed.ncbi.nlm.nih.gov/40038742/
2. Yuan, Ningning, Wang, Jiechen, Zhou, Yong, Wang, Wenqin, Wu, Yongrui. 2019. EMB-7L is required for embryogenesis and plant development in maize involved in RNA splicing of multiple chloroplast genes. In Plant science : an international journal of experimental plant biology, 287, 110203. doi:10.1016/j.plantsci.2019.110203. https://pubmed.ncbi.nlm.nih.gov/31481208/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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