Logo
Homepage
Explore Our Models
My Cart
Contact
Subscribe
Models
Genetically Engineered Animals
Knockout Mice
Knockout Rats
Knockin Mice
Knockin Rats
Transgenic Mice
Transgenic Rats
Model Generation Techniques
Turboknockout<sup>®</sup> Gene Targeting
ES Cell Gene Targeting
Targeted Gene Editing
Regular Transgenic
PiggyBac Transgenesis
BAC Transgenic
Research Models
HUGO-GT™ Humanized Mice
Cre Mouse Lines
Humanized Target Gene Models
Metabolic Disease Models
Ophthalmic Disease Models
Neurological Disease Models
Autoimmune Disease Models
Immunodeficient Mouse Models
Humanized Immune System Mouse Models
Oncology & Immuno-oncology Models
Covid-19 Mouse Models
MouseAtlas Model Library
Knockout Cell Line Product Catalog
Tumor Cell Line Product Catalog
AAV Standard Product Catalog
Animal Supporting Services
Breeding Services
Cryopreservation & Recovery
Phenotyping Services
BAC Modification
Custom Cell Line Models
Induced Pluripotent Stem Cells (iPSCs)
Knockout Cell Lines
Knockin Cell Lines
Point Mutation Cell Lines
Overexpression Cell Lines
Virus Packaging
Adeno-associated Virus (AAV) Packaging
Lentivirus Packaging
Adenovirus Packaging
CRO Services
By Therapeutic Area
Oncology
Ophthalmology
Neuroscience
Metabolic & Cardiovascular Diseases
Autoimmune & Inflammatory
By Drug Type
AI-Powered AAV Discovery
Gene Therapy
Oligonucleotide Therapy
Antibody Therapy
Cell Immunotherapy
Resources
Promotion
Events & Webinars
Newsroom
Blogs & Insights
Resource Vault
Reference Databases
Peer-Reviewed Citations
Rare Disease Data Center
AbSeek
Cell iGeneEditor™ System
OriCell
Quality
Facility Overview
Animal Health & Welfare
Health Reports
About Us
Corporate Overview
Our Partners
Careers
Contact Us
Login
Request a Product Quote
Select products from our catalogs and submit your request. Our team will get back to you with detailed information.
Full Name
Email
Phone Number
Organization
Job Role
Country
Catalog Type
Product Name
Additional Comments
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.
C57BL/6JCya-Vps37dem1/Cya
Common Name:
Vps37d-KO
Product ID:
S-KO-17176
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Vps37d-KO
Strain ID
KOCMP-194309-Vps37d-B6J-VA
Gene Name
Vps37d
Product ID
S-KO-17176
Gene Alias
Wbscr24
Background
C57BL/6JCya
NCBI ID
194309
Modification
Conventional knockout
Chromosome
5
Phenotype
MGI:2159402
Document
Click here to download >>
Application
--
More
Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Vps37dem1/Cya mice (Catalog S-KO-17176) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000067935
NCBI RefSeq
NM_001199677.1
Target Region
Exon 2
Size of Effective Region
~172 bp
Detailed Document
Click here to download >>
Overview of Gene Research
Vps37d, a component of the ESCRT-I complex, is crucial for multivesicular body formation and exosome biogenesis, processes involved in the traffic of molecules between cellular organelles [2]. It may play a role in pathways related to cell-cell interactions, as it has been associated with genes involved in neuronal development processes like cell adhesion, migration, growth, and cytoskeleton formation [1].

In a disabled boy with a complex chromosomal rearrangement t(5;7;21)dn, the Vps37d gene was disrupted, along with other genes involved in normal neuronal development. Although the disruption of TRIO was most likely the cause of the patient's MRD44-like phenotype, Vps37d may also cooperate in these key biological processes for neuronal development [1]. In corneal stromal cells from keratoconus patients, the mRNA of Vps37d was underexpressed, suggesting that disruptions in the exosome synthesis machinery, in which Vps37d is involved, may contribute to the altered molecular content of exosomes in keratoconus [2]. Frameshift mutations of Vps37d were found in gastric and colorectal cancers with high microsatellite instability, indicating that these alterations might contribute to the development of such cancers by deregulating vacuolar protein sorting proteins [3]. Also, pan-cancer analysis shows that the Vps37D gene has significant variation in breast cancer, predicting patient prognosis and being related to the tumor microenvironment, suggesting it could be a novel biomarker for early diagnosis and prognosis assessment [4].

In conclusion, Vps37d is important for exosome biogenesis and multivesicular body formation. Its disruption or abnormal expression is associated with neurodevelopmental disorders, keratoconus, and certain cancers. Studies on Vps37d contribute to understanding the mechanisms of these diseases and may provide potential diagnostic and prognostic markers.

References:

1. Córdova-Fletes, Carlos, Rivera, Horacio, Aguayo-Orozco, Thania Alejandra, Esparza-García, Eduardo, Domínguez-Quezada, Ma Guadalupe. 2022. A chromoanagenesis-driven ultra-complex t(5;7;21)dn truncates neurodevelopmental genes in a disabled boy as revealed by whole-genome sequencing. In European journal of medical genetics, 65, 104579. doi:10.1016/j.ejmg.2022.104579. https://pubmed.ncbi.nlm.nih.gov/35933106/

2. Blanco-Agudín, Noelia, Ye, Suhui, Alcalde, Ignacio, Merayo-Lloves, Jesús, Quirós, Luis M. 2025. Corneal stromal cells from patients with keratoconus exhibit alterations in the ESCRT-dependent machinery responsible for multivesicular body formation. In Experimental eye research, 252, 110260. doi:10.1016/j.exer.2025.110260. https://pubmed.ncbi.nlm.nih.gov/39890050/

3. An, Chang Hyeok, Kim, Yoo Ri, Kim, Ho Shik, Yoo, Nam Jin, Lee, Sug Hyung. 2011. Frameshift mutations of vacuolar protein sorting genes in gastric and colorectal cancers with microsatellite instability. In Human pathology, 43, 40-7. doi:10.1016/j.humpath.2010.03.015. https://pubmed.ncbi.nlm.nih.gov/21733561/

4. Chen, Xiao-Rui, Tan, Xue-Ying, Zhang, Zong-Liang, Yuan, Jiang-Shui, Song, Wei-Qing. 2025. ESCRT may function as a tumor biomarker, transitioning from pan-cancer analysis to validation within breast cancer. In Frontiers in immunology, 16, 1531940. doi:10.3389/fimmu.2025.1531940. https://pubmed.ncbi.nlm.nih.gov/40230849/

Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Model Library
Model Library
Resources
Resources
Animal Quality
Animal Quality
Get Support
Get Support
Address:
2255 Martin Avenue, Suite E Santa Clara, CA 95050-2709, US
Tel:
800-921-8930 (8-6pm PST)
+1408-963-0306 (lnt’l)
Fax:
408-969-0338
Email:
animal-service@cyagen.com
service@cyagen.us
CRO Services
OncologyOphthalmologyNeuroscienceMetabolic & CardiovascularAutoimmune & InflammatoryGene TherapyAntibody Therapy
About Us
Corporate OverviewOur PartnersCareersContact Us
Social Media
Disclaimer: Pricing and availability of our products and services vary by region. Listed prices are applicable to the specific countries. Please contact us for more information.
Copyright © 2025 Cyagen. All rights reserved.
Privacy Policy
Site Map
Stay Updated with the Latest from Cyagen
Get the latest news on our research models, CRO services, scientific resources, and special offers—tailored to your research needs and delivered straight to your inbox.
Full Name
Email
Organization
Country
Areas of Interest