C57BL/6JCya-Ogfrem1/Cya
Common Name
Ogfr-KO
Product ID
S-KO-17228
Backgroud
C57BL/6JCya
Strain ID
KOCMP-72075-Ogfr-B6J-VB
When using this mouse strain in a publication, please cite “Ogfr-KO Mouse (Catalog S-KO-17228) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Ogfr-KO
Strain ID
KOCMP-72075-Ogfr-B6J-VB
Gene Name
Product ID
S-KO-17228
Gene Alias
2010013E17Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 2
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000029087
NCBI RefSeq
NM_031373
Target Region
Exon 2~3
Size of Effective Region
~2.1 kb
Overview of Gene Research
Ogfr, the opioid growth factor receptor, is a key component in the OGF-OGFr regulatory pathway. The native opioid growth factor (OGF), [Met(5)]-enkephalin, binds to OGFr. This pathway is involved in diverse biological processes such as cell proliferation, tissue organization during development, cancer, cellular renewal, wound healing, and angiogenesis [4].
Silencing OGFR through gene knockout effectively alleviated doxorubicin-induced cardiotoxicity in mice, suggesting that the OGF/OGFR/P21 axis facilitates cardiomyocyte apoptosis related to doxorubicin-induced cardiotoxicity [1]. In addition, blockade of the OGF-OGFr pathway using naltrexone in type 1 diabetic rats reversed dry eye symptoms and restored corneal surface sensitivity, and also accelerated some aspects of delayed diabetic fracture repair [2,3].
In conclusion, OGFr plays a significant role in multiple biological processes and disease conditions. Gene knockout models of OGFr have revealed its importance in chemotherapy-induced cardiotoxicity and diabetic complications, including ocular and bone-related issues. These findings provide potential therapeutic targets for treating such diseases.
References:
1. Chen, Xiru, Jian, Dongdong, Xing, Junyue, Jian, Liguo, Tang, Hao. 2024. Targeting OGF/OGFR signal to mitigate doxorubicin-induced cardiotoxicity. In Free radical biology & medicine, 223, 398-412. doi:10.1016/j.freeradbiomed.2024.08.005. https://pubmed.ncbi.nlm.nih.gov/39122201/
2. Zagon, Ian S, Sassani, Joseph W, Purushothaman, Indira, McLaughlin, Patricia J. 2020. Blockade of OGFr delays the onset and reduces the severity of diabetic ocular surface complications. In Experimental biology and medicine (Maywood, N.J.), 246, 629-636. doi:10.1177/1535370220972060. https://pubmed.ncbi.nlm.nih.gov/33203224/
3. Titunick, Michelle B, Lewis, Gregory S, Cain, Jarrett D, Zagon, Ian S, McLaughlin, Patricia J. 2019. Blockade of the OGF-OGFr pathway in diabetic bone. In Connective tissue research, 60, 521-529. doi:10.1080/03008207.2019.1593396. https://pubmed.ncbi.nlm.nih.gov/30931654/
4. Zagon, Ian S, Verderame, Michael F, McLaughlin, Patricia J. . The biology of the opioid growth factor receptor (OGFr). In Brain research. Brain research reviews, 38, 351-76. doi:. https://pubmed.ncbi.nlm.nih.gov/11890982/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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