C57BL/6JCya-Sema6bem1/Cya
Common Name
Sema6b-KO
Product ID
S-KO-17252
Backgroud
C57BL/6JCya
Strain ID
KOCMP-20359-Sema6b-B6J-VB
When using this mouse strain in a publication, please cite “Sema6b-KO Mouse (Catalog S-KO-17252) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Sema6b-KO
Strain ID
KOCMP-20359-Sema6b-B6J-VB
Gene Name
Product ID
S-KO-17252
Gene Alias
Sema, Seman, VIb, semaZ
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 17
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000001256
NCBI RefSeq
NM_001130456.1
Target Region
Exon 4~7
Size of Effective Region
~1.6 kb
Overview of Gene Research
Sema6b, a member of the semaphorin axon-guidance family, plays diverse roles in biological processes. It is involved in axon guidance, neuronal development including spine formation and maturation, and may be associated with immune-related pathways. Genetic models such as gene knockout mice are valuable for studying its functions [2].
In hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), Sema6b knockout mice showed improved liver functions, reduced inflammatory responses, and decreased hepatocyte apoptosis. Transcriptome analysis of their liver tissue revealed significant down-regulation of inflammation-related pathways. This indicates that Sema6b exacerbates liver failure through macrophage-mediated systemic inflammation and hepatocyte apoptosis, and could be a potential diagnostic biomarker and early treatment target for HBV-ACLF [1]. In neuronal development, knockdown of Sema6b in neuronal cultures impaired spine density and maturation, and in chicken embryos, mutated forms of Sema6b failed to rescue the normal axon pathway after endogenous Sema6b knockdown, highlighting its role in neuronal development [2].
In conclusion, Sema6b is crucial in neuronal development and has a significant impact on liver failure progression. Gene knockout models, especially in the context of HBV-ACLF, have revealed its role in inflammation and apoptosis, providing potential therapeutic targets for this life-threatening liver condition. Additionally, its role in neuronal development underscores its importance in neurobiology [1,2].
References:
1. Yang, Hui, Cai, Qun, Xin, Jiaojiao, Shi, Dongyan, Li, Jun. 2024. SEMA6B induces macrophage-mediated inflammation and hepatocyte apoptosis in hepatitis B virus-related acute-on-chronic liver failure. In Theranostics, 14, 5200-5218. doi:10.7150/thno.97007. https://pubmed.ncbi.nlm.nih.gov/39267780/
2. Cordovado, Amélie, Schaettin, Martina, Jeanne, Médéric, Toutain, Annick, Vuillaume, Marie-Laure. . SEMA6B variants cause intellectual disability and alter dendritic spine density and axon guidance. In Human molecular genetics, 31, 3325-3340. doi:10.1093/hmg/ddac114. https://pubmed.ncbi.nlm.nih.gov/35604360/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.