C57BL/6JCya-Arl13aem1/Cya
Common Name
Arl13a-KO
Product ID
S-KO-17288
Backgroud
C57BL/6JCya
Strain ID
KOCMP-74448-Arl13a-B6J-VB
When using this mouse strain in a publication, please cite “Arl13a-KO Mouse (Catalog S-KO-17288) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Arl13a-KO
Strain ID
KOCMP-74448-Arl13a-B6J-VB
Gene Name
Product ID
S-KO-17288
Gene Alias
4933422M21Rik, Arl13
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr X
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000064476
NCBI RefSeq
NM_028947
Target Region
Exon 4
Size of Effective Region
~1.1 kb
Overview of Gene Research
Arl13a, a member of the Arf-like (Arl) family of small GTP-binding proteins, is a close paralog to Arl13b. These proteins are involved in regulating various cellular functions and play crucial roles in cilia structure and signaling. Genetic models, like zebrafish, can be valuable for studying Arl13a [1].
In zebrafish, Arl13a and Arl13b are both widely expressed during early cell division and gastrulation, localizing to microtubules in ciliated and dividing cells. However, between 2-5 days post-fertilization, Arl13b is expressed in neural tissues while Arl13a expression is downregulated by 2 dpf and restricted to craniofacial structures, indicating different evolved roles and suggesting Arl13a does not function in the zebrafish retina [1]. In cheetahs, mutations in Arl13a, along with three other genes (DEFB116, CFAP119, and NT5DC4), are linked to male fertility and immune deficiencies, likely due to pseudogenization events [2,3].
In conclusion, Arl13a is involved in cilia-related functions and may have tissue-specific expression patterns during development. The findings from zebrafish and cheetah studies suggest its role in non-retinal development in zebrafish and its potential link to male fertility and immune deficiencies in cheetahs, highlighting its importance in understanding both normal development and certain disease-related conditions.
References：
1. Song, Ping, Perkins, Brian D. 2018. Developmental expression of the zebrafish Arf-like small GTPase paralogs arl13a and arl13b. In Gene expression patterns : GEP, 29, 82-87. doi:10.1016/j.gep.2018.07.002. https://pubmed.ncbi.nlm.nih.gov/30009987/
2. Ghader, Aryan. 2025. Digest: Do weakly deleterious mutations exacerbate reproductive and health challenges in species with prolonged bottlenecks? In Evolution; international journal of organic evolution, , . doi:10.1093/evolut/qpaf046. https://pubmed.ncbi.nlm.nih.gov/40089805/
3. Peers, Jessica A, Nash, Will J, Haerty, Wilfried. . Gene pseudogenization in fertility-associated genes in cheetah (Acinonyx jubatus), a species with long-term low effective population size. In Evolution; international journal of organic evolution, 79, 574-585. doi:10.1093/evolut/qpaf005. https://pubmed.ncbi.nlm.nih.gov/39821281/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
Contact Us
Connect with our experts for your custom animal model needs. Please fill out the form below to start a conversation or request a quote.
Cyagen values your privacy. We’d like to keep you informed about our latest offerings and insights. Your preferences:
You may unsubscribe from these communications at any time. See our Privacy Policy for details on opting out and data protection.
By clicking the button below, you consent to allow Cyagen to store and process the personal information submitted in this form to provide you the content requested.