C57BL/6JCya-Vsig2em1/Cya
Common Name:
Vsig2-KO
Product ID:
S-KO-17311
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Vsig2-KO
Strain ID
KOCMP-57276-Vsig2-B6J-VB
Gene Name
Product ID
S-KO-17311
Gene Alias
1190004B15Rik; 2210413P10Rik; CTX; Ctm
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
9
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Vsig2em1/Cya mice (Catalog S-KO-17311) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000002008
NCBI RefSeq
NM_020518
Target Region
Exon 1~6
Size of Effective Region
~5.0 kb
Detailed Document
Overview of Gene Research
Vsig2, or V-set and immunoglobulin domain containing 2, belongs to the immunoglobulin superfamily (IgSF) and functions as a coinhibitory molecule, mediating immune evasion of tumors [1]. It has been associated with multiple biological processes and disease-related pathways, including those involved in cancer progression, immune response, and potentially cardiovascular health [1,2,3]. Genetic models such as knockout (KO) or conditional knockout (CKO) mouse models could potentially be valuable in further exploring its function.
In pancreatic ductal adenocarcinoma (PDAC), VSIG2 was highly expressed in tissues and cells. Overexpression of VSIG2 facilitated the proliferation, invasion, and migration of PDAC cells, while its inhibition had opposite effects. Mechanistically, VSIG2 bound to LAMTOR2 and mTOR, enhancing their interaction and leading to elevated mTOR phosphorylation and activation of downstream molecules [1]. In colon cancer, VSIG2 was identified as a key candidate gene through weighted gene co-expression network analysis. Its encoded protein was mainly expressed in immune cells, and its expression was positively correlated with immune infiltration, suggesting it plays a role in immune invasion and antigen presentation in colon adenocarcinoma (COAD) [2].
In conclusion, VSIG2 is a gene with significant implications in cancer-related biological processes. The findings from studies related to PDAC and colon cancer highlight its potential as a biomarker for diagnosis and prognosis, as well as a novel therapeutic target. Research on VSIG2 using gene knockout or conditional knockout mouse models could further elucidate its role in disease mechanisms, potentially leading to new strategies for disease treatment and prevention [1,2].
References:
1. Xu, Jichuan, Quan, Gang, Huang, Wei, Jiang, Jianxin. 2023. VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma by enhancing LAMTOR2-mediated mTOR activation. In Cell communication and signaling : CCS, 21, 223. doi:10.1186/s12964-023-01209-x. https://pubmed.ncbi.nlm.nih.gov/37626304/
2. Cui, Zhongze, Li, Yangyang, He, Shuang, Lu, Lizhen, Wu, Shuhua. 2021. Key Candidate Genes - VSIG2 of Colon Cancer Identified by Weighted Gene Co-Expression Network Analysis. In Cancer management and research, 13, 5739-5750. doi:10.2147/CMAR.S316584. https://pubmed.ncbi.nlm.nih.gov/34290531/
3. Plaza-Florido, Abel, Olvera-Rojas, Marcos, Alcantara, Juan M A, Radom-Aizik, Shlomit, Ortega, Francisco B. 2024. Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight/obesity. In American journal of human biology : the official journal of the Human Biology Council, 36, e24113. doi:10.1002/ajhb.24113. https://pubmed.ncbi.nlm.nih.gov/38864311/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen