C57BL/6JCya-Defb43em1/Cya
Common Name
Defb43-KO
Product ID
S-KO-17314
Backgroud
C57BL/6JCya
Strain ID
KOCMP-654458-Defb43-B6J-VB
When using this mouse strain in a publication, please cite “Defb43-KO Mouse (Catalog S-KO-17314) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Defb43-KO
Strain ID
KOCMP-654458-Defb43-B6J-VB
Gene Name
Product ID
S-KO-17314
Gene Alias
BD-43, EG654458, mBD-43
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 14
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000100491
NCBI RefSeq
NM_001039121
Target Region
Exon 2
Size of Effective Region
~0.3 kb
Overview of Gene Research
Defb43, also known as defensin beta 43, is a gene involved in innate immunity. Innate immunity is a crucial first-line defense mechanism in the body against various pathogens. Genes like Defb43 play a significant role in maintaining the body's natural defense system, which is essential for overall health and protection from infectious diseases [1].
In a study on adult female C57BL/6 mice masculinized by testosterone, among the 17,354 promoters examined, the Cor-promoter region of Defb43 was one of the identified 15 Cor-promoters of genes with annotated functions. Testosterone decreased DNA-methylation of the Cor-promoter region of Defb43, suggesting an epigenetic effect on this gene involved in innate immunity [1].
In conclusion, Defb43 is integral to the innate immune system. The study on testosterone-masculinized mice reveals that epigenetic modifications, such as changes in DNA-methylation of its promoter region, can potentially impact its function in innate immunity. Understanding these relationships may provide insights into how hormonal changes can influence the body's natural defense mechanisms at a genetic level [1].
References：
1. Dkhil, Mohamed A, Al-Quraishy, Saleh, Abdel-Baki, Abdel-Azeem, Delic, Denis, Wunderlich, Frank. 2014. Epigenetic modifications of gene promoter DNA in the liver of adult female mice masculinized by testosterone. In The Journal of steroid biochemistry and molecular biology, 145, 121-30. doi:10.1016/j.jsbmb.2014.11.006. https://pubmed.ncbi.nlm.nih.gov/25448745/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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