C57BL/6JCya-Fam107aem1/Cya
Common Name:
Fam107a-KO
Product ID:
S-KO-17347
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Fam107a-KO
Strain ID
KOCMP-268709-Fam107a-B6J-VA
Gene Name
Product ID
S-KO-17347
Gene Alias
DRR1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
14
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fam107aem1/Cya mice (Catalog S-KO-17347) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000120411
NCBI RefSeq
NM_001360339
Target Region
Exon 3
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
FAM107A, Family with sequence similarity 107 member A, has been recognized as a potential tumor suppressor in various malignancies. It is involved in regulating tumor cell proliferation, migration, invasion, and apoptosis. In terms of associated pathways, it has been linked to the FAK/PI3K/AKT signaling pathway [2], and KEGG and GO enrichment analysis suggest "cell adhesion" and "cAMP signaling pathway" as potential impacts [4]. Genetic models are valuable for further exploring its functions.
In multiple cancers, including esophageal squamous carcinoma [1], prostate cancer [2], bladder cancer [3], lung adenocarcinoma [5], non-small cell lung cancer [6], and colorectal cancer [7], FAM107A shows reduced expression. In these cases, low FAM107A expression is associated with poor prognosis and unfavorable clinicopathological characteristics. Overexpression of FAM107A in cancer cell lines and in vivo xenograft models inhibits tumor cell growth, invasion, migration, and the epithelial-mesenchymal transition process, and promotes apoptosis. For example, in prostate cancer, its inactivation due to promoter methylation affects cancer progression through the FAK/PI3K/AKT pathway [2]. In bladder cancer, restoring FAM107A suppresses cell growth, migration, and invasion [3].
In summary, FAM107A functions as a potential tumor suppressor, inhibiting the malignant behavior of cancer cells. Studies using cell lines and in vivo models, such as xenograft tumors, have revealed its significance in cancer development. Understanding FAM107A's role provides potential therapeutic targets for cancers like esophageal squamous carcinoma, prostate cancer, bladder cancer, and others.
References:
1. Zhang, Jiale, Di, Shouyin, Li, Mingyang, Jia, Qingge, Fan, Boshi. 2023. FAM107A as a tumor suppressor in esophageal squamous carcinoma inhibits growth and metastasis. In Pathology, research and practice, 252, 154945. doi:10.1016/j.prp.2023.154945. https://pubmed.ncbi.nlm.nih.gov/37977035/
2. Ke, Shuai, Liu, Zelin, Wang, Qinghua, Yu, Xi, Guo, Jia. 2022. FAM107A Inactivation Associated with Promoter Methylation Affects Prostate Cancer Progression through the FAK/PI3K/AKT Pathway. In Cancers, 14, . doi:10.3390/cancers14163915. https://pubmed.ncbi.nlm.nih.gov/36010909/
3. Ou, Longhua, Wei, Zhengmao, Xu, Jinming, Wang, Yan, Shi, Bentao. . FAM107A as a Tumor Suppressor in Bladder Cancer Inhibits Cell Proliferation, Migration, and Invasion. In Annals of clinical and laboratory science, 52, 260-268. doi:. https://pubmed.ncbi.nlm.nih.gov/35414505/
4. Ou, Dehua, Zhang, Zhiqin, Wu, Zesong, She, Sifan, Lin, Ming-En. 2022. Identification of the Putative Tumor Suppressor Characteristics of FAM107A via Pan-Cancer Analysis. In Frontiers in oncology, 12, 861281. doi:10.3389/fonc.2022.861281. https://pubmed.ncbi.nlm.nih.gov/35669436/
5. Ming, Fei, Zhang, DaiPing. 2025. FAM107A Inhibits the Growth, Invasion and Aerobic Glycolysis of LUAD Cells by Regulating CRYAB/PI3K/AKT. In Biochemical genetics, , . doi:10.1007/s10528-024-11006-x. https://pubmed.ncbi.nlm.nih.gov/39751722/
6. Pastuszak-Lewandoska, D, Czarnecka, K H, Migdalska-Sęk, M, Górski, P, Brzeziańska-Lasota, E. . Decreased FAM107A Expression in Patients with Non-small Cell Lung Cancer. In Advances in experimental medicine and biology, 852, 39-48. doi:10.1007/5584_2014_109. https://pubmed.ncbi.nlm.nih.gov/25753555/
7. Wang, Di, Feng, Meina, Ma, Xianxiong, Tao, Kaixiong, Wang, Guobin. 2021. Transcription factor SP1-induced microRNA-146b-3p facilitates the progression and metastasis of colorectal cancer via regulating FAM107A. In Life sciences, 277, 119398. doi:10.1016/j.lfs.2021.119398. https://pubmed.ncbi.nlm.nih.gov/33831429/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen