C57BL/6JCya-Fdpsem1/Cya
Common Name:
Fdps-KO
Product ID:
S-KO-17375
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Fdps-KO
Strain ID
KOCMP-110196-Fdps-B6J-VA
Gene Name
Product ID
S-KO-17375
Gene Alias
6030492I17Rik; Fdpsl1; mKIAA1293
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Fdpsem1/Cya mice (Catalog S-KO-17375) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000081848
NCBI RefSeq
NM_134469
Target Region
Exon 2~3
Size of Effective Region
~2.6 kb
Detailed Document
Overview of Gene Research
Fdps, also known as Farnesyl diphosphate synthase, is an enzyme in the mevalonate pathway. This pathway is crucial for the synthesis of important molecules like cholesterol and isoprenoids. Fdps catalyzes the production of farnesyl diphosphate, which is a key intermediate in multiple downstream biosynthetic processes, thus being of great biological importance in various cellular functions [1].
In prostate cancer, in vitro and in vivo studies using PTEN-conditionally knockout mice showed that FDPS overexpression synergizes with PTEN deficiency. FDPS promotes oncogenic phenotypes such as colony formation and proliferation through activation of AKT and ERK signaling by prenylating Rho A, Rho G, and CDC42 small GTPases. In glioma, FDPS level is enhanced in tissues, contributing to tumour growth. It activates the Wnt/β-catenin signalling pathway and facilitates macrophage infiltration by inducing CCL20 expression [1,2].
In conclusion, Fdps plays a significant role in cancer-related biological processes. Through in vivo studies using gene knockout models like PTEN-conditionally knockout mice, the oncogenic role of Fdps in prostate cancer and glioma has been revealed. These findings provide insights into potential therapeutic targets for these diseases, highlighting the importance of Fdps in understanding cancer development mechanisms.
References:
1. Seshacharyulu, Parthasarathy, Rachagani, Satyanarayana, Muniyan, Sakthivel, Datta, Kaustubh, Batra, Surinder K. 2019. FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis. In Oncogene, 38, 5265-5280. doi:10.1038/s41388-019-0791-9. https://pubmed.ncbi.nlm.nih.gov/30914801/
2. Chen, Zhuo, Chen, Guangyong, Zhao, Hang. 2020. FDPS promotes glioma growth and macrophage recruitment by regulating CCL20 via Wnt/β-catenin signalling pathway. In Journal of cellular and molecular medicine, 24, 9055-9066. doi:10.1111/jcmm.15542. https://pubmed.ncbi.nlm.nih.gov/32596949/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen