C57BL/6JCya-F2rl2em1/Cya
Common Name:
F2rl2-KO
Product ID:
S-KO-17400
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
F2rl2-KO
Strain ID
KOCMP-14064-F2rl2-B6J-VB
Gene Name
Product ID
S-KO-17400
Gene Alias
F730031A08; PAR3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-F2rl2em1/Cya mice (Catalog S-KO-17400) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000022182
NCBI RefSeq
NM_010170.4
Target Region
Exon 2
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
F2rl2, also known as coagulation factor II thrombin receptor-like 2 or protease-activated receptor-3 (PAR3), is a G-protein-coupled receptor. It is involved in multiple biological processes. For instance, in the context of blood-related processes, it may be associated with coagulation pathways. It also seems to play a role in cellular signaling as its activation by thrombin can regulate various cellular responses [3].
In the study of myocardial infarction, both NFAT2 silencing and F2RL2 silencing relieved the damage and inflammation in MI model mice. miR-125b-5p alleviated MI injury by inhibiting NFAT2 to reduce F2RL2 expression [1]. Additionally, downregulation of F2RL2 in MI mice prevented the reduction in left ventricular ejection fraction (EF) and fractional shortening (FS), and the elevation in infarct area and cell apoptosis. lncRNA NEAT1 downregulation ameliorated MI by regulating the miR-582-5p/F2RL2 axis [2].
In conclusion, F2rl2 is involved in crucial biological processes, especially in the context of myocardial infarction. The use of gene-silencing techniques in mouse models related to F2rl2 has revealed its role in reducing damage and inflammation in myocardial infarction, providing potential therapeutic targets for this disease.
References：
1. Wu, Zhenhua, Geng, Jie, Bai, Yunpeng, Jiao, Yan, Guo, Zhigang. 2023. miR-125b-5p alleviates the damage of myocardial infarction by inhibiting the NFAT2 to reduce F2RL2 expression. In Regenerative medicine, 18, 543-559. doi:10.2217/rme-2022-0150. https://pubmed.ncbi.nlm.nih.gov/37340944/
2. Wu, Zhenhua, Bai, Yunpeng, Qi, Yujuan, Bai, Yaobang, Guo, Zhigang. 2022. lncRNA NEAT1 Downregulation Ameliorates the Myocardial Infarction of Mice by Regulating the miR-582-5p/F2RL2 Axis. In Cardiovascular therapeutics, 2022, 4481360. doi:10.1155/2022/4481360. https://pubmed.ncbi.nlm.nih.gov/36540097/
3. Hänzelmann, Sonja, Wang, Jinling, Güney, Emre, Castelo, Robert, Rosengren, Anders H. . Thrombin stimulates insulin secretion via protease-activated receptor-3. In Islets, 7, e1118195. doi:10.1080/19382014.2015.1118195. https://pubmed.ncbi.nlm.nih.gov/26742564/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen