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C57BL/6JCya-Mettl24em1/Cya
Common Name:
Mettl24-KO
Product ID:
S-KO-17440
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Mettl24-KO
Strain ID
KOCMP-327747-Mettl24-B6J-VB
Gene Name
Mettl24
Product ID
S-KO-17440
Gene Alias
9030224M15Rik
Background
C57BL/6JCya
NCBI ID
327747
Modification
Conventional knockout
Chromosome
10
Phenotype
MGI:3045338
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Mettl24em1/Cya mice (Catalog S-KO-17440) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000058747
NCBI RefSeq
NM_177793.3
Target Region
Exon 3
Size of Effective Region
~1.7 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Mettl24, also known as Methyltransferase like 24, is a member of the methyltransferase-like family. Although its exact essential function is yet to be fully elucidated, it potentially participates in immune-relevant biological processes such as cytokine binding, NF-kappa B binding, MHC protein complex, and interleukin-12 action [1].

In kidney renal clear cell carcinoma (KIRC), Mettl24 expression in tumor tissues is significantly decreased compared to normal adjacent kidney tissues, which is associated with a lower survival rate of KIRC patients. It is linked to a number of immune checkpoints, cytokines, chemokines, and chemokine receptors, and also correlated with the infiltration levels of 10 types of immune cells in KIRC. Additionally, CTCF and EP300 were discovered to be the probable transcription factors of Mettl24 in KIRC [1]. In rectal cancer, genes of highly correlated lncRNA-mRNA pairs including Mettl24 presented strong prognosis effects [2]. Also, in children with early rhinovirus-induced wheezing developing atopic asthma, DNA methylation changes were detected in the introns of DDO/METTL24 genes [3].

In conclusion, Mettl24 seems to be involved in immune-related biological processes and is associated with diseases like KIRC and rectal cancer. Its expression levels and associated methylation changes may play crucial roles in these disease conditions. The findings related to Mettl24 contribute to understanding the biological mechanisms underlying these diseases and potentially offer new prognostic and therapeutic targets.

References:
1. Jiang, Zhongji, Zhang, Wei, Zeng, Zhipeng, Xu, Yong, Dai, Yong. 2022. A comprehensive investigation discovered the novel methyltransferase METTL24 as one presumably prognostic gene for kidney renal clear cell carcinoma potentially modulating tumor immune microenvironment. In Frontiers in immunology, 13, 926461. doi:10.3389/fimmu.2022.926461. https://pubmed.ncbi.nlm.nih.gov/36311770/
2. Cai, Guoying, Sun, Meifei, Li, Xinrong, Zhu, Junquan. 2021. Construction and characterization of rectal cancer-related lncRNA-mRNA ceRNA network reveals prognostic biomarkers in rectal cancer. In IET systems biology, 15, 192-204. doi:10.1049/syb2.12035. https://pubmed.ncbi.nlm.nih.gov/34613665/
3. Lund, R J, Osmala, M, Malonzo, M, Lahesmaa, R, Jartti, T. 2018. Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter. In Allergy, 73, 1735-1740. doi:10.1111/all.13473. https://pubmed.ncbi.nlm.nih.gov/29729188/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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