C57BL/6JCya-Ighmem1/Cya
Common Name:
Ighm-KO
Product ID:
S-KO-17454
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ighm-KO
Strain ID
KOCMP-16019-Ighm-B6J-VA
Gene Name
Product ID
S-KO-17454
Gene Alias
Igh-6; Igh-M; Igh6; Igm; muH
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
12
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ighmem1/Cya mice (Catalog S-KO-17454) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000103426
NCBI RefSeq
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Target Region
Exon 4
Size of Effective Region
~1.4 kb
Detailed Document
Overview of Gene Research
Ighm, short for immunoglobulin heavy constant mu, is a gene involved in the differentiation of B lymphocytes, which is accompanied by a regulated switch in the expression pattern and stability of surface and secretory immunoglobulins (Igs). It is an important part of the immune response system, with its associated pathways likely influencing humoral immunity. Genetic models, such as gene knockout mouse models, can be valuable in further understanding its functions [1].
A study on 255 subjects from 59 Tunisian families genotyped for 15 SNPs mapping in 4 regions in the IGH locus found that several single-nucleotide polymorphisms (SNPs) of Ighm, including rs1950942, rs2180790, rs1808152, and rs1956596, were significantly associated with a risk for type 1 diabetes (T1D). The TATGG haplotype derived from linkage disequilibrium (LD) across three SNPs from Ighm gene and two SNPs from IGHD gene was significantly over-transmitted from parents to affected offspring. These genetic variants at the IGH locus may predispose to IgG autoantibodies (AutoAbs) production against pancreatic antigens and AutoAbs multi-reactivity, leading to T1D development [1].
In conclusion, Ighm plays a crucial role in the immune response, especially in the context of B lymphocyte differentiation. The findings from the genetic association study of Ighm SNPs with T1D susceptibility highlight the importance of Ighm in autoimmune disease research. Mouse models targeting Ighm could potentially further elucidate its role in T1D and other immune-related diseases.
References:
1. Ferjeni, Zouidi, Raouia, Fakhfakh, Abida, O, Penha-Gonçalves, C, Masmoudi, H. 2022. Association of IGHM polymorphisms with susceptibility to type 1 diabetes. In Immunologic research, 70, 325-330. doi:10.1007/s12026-021-09252-x. https://pubmed.ncbi.nlm.nih.gov/35048256/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen