C57BL/6JCya-Prdx2em1/Cya
Common Name:
Prdx2-KO
Product ID:
S-KO-17474
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Prdx2-KO
Strain ID
KOCMP-21672-Prdx2-B6J-VA
Gene Name
Product ID
S-KO-17474
Gene Alias
Band-8; NkefB; PRP; PrxII; TDX1; TPx; TPx-B; TR; TSA; Tdpx1; Torin
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
8
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Prdx2em1/Cya mice (Catalog S-KO-17474) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000005292
NCBI RefSeq
NM_011563
Target Region
Exon 4~5
Size of Effective Region
~1.5 kb
Detailed Document
Overview of Gene Research
Prdx2, a characteristic 2-Cys enzyme, is one of the most effective scavenger proteins against reactive oxygen species (ROS) and hydrogen peroxide (H2O2), protecting cells from oxidative stress. It is involved in multiple signaling pathways and plays a crucial role in maintaining cellular redox balance. Dysregulation of Prdx2 can lead to increased ROS levels and oxidative stress, which are implicated in various diseases [2].
In a study on non-alcoholic steatohepatitis (NASH), liver-specific Prdx2 knockout (Prdx2 LKO) female mice fed a methionine-choline deficient diet (MCD) showed a significant increase in hepatic lipid accumulation, inflammation, circulating aspartate aminotransferase (AST) levels, and activation of pro-inflammatory signaling pathways. There was also an increase in lipid peroxidation in the liver, suggesting that Prdx2 deficiency exacerbates MCD-induced NASH in female mice and indicating a protective role of Prdx2 [3]. In another study, endothelial-specific overexpression of Prdx2 improved cardiac microvascular function in a manner similar to isorhapontigenin treatment, and Prdx2 mediated the inhibition of ferroptosis by suppressing oxidative stress, iron overload, and lipid peroxidation [1].
In conclusion, Prdx2 is essential for maintaining cellular redox balance and has a protective role in various disease conditions. The use of Prdx2 knockout mouse models has provided valuable insights into its role in diseases such as NASH and cardiac microvascular injury, highlighting its potential as a therapeutic target for these diseases.
References:
1. Chen, Yuqiong, Li, Su, Yin, Ming, Chen, Zhangwei, Qian, Juying. . Isorhapontigenin Attenuates Cardiac Microvascular Injury in Diabetes via the Inhibition of Mitochondria-Associated Ferroptosis Through PRDX2-MFN2-ACSL4 Pathways. In Diabetes, 72, 389-404. doi:10.2337/db22-0553. https://pubmed.ncbi.nlm.nih.gov/36367849/
2. Balasubramanian, Priyanka, Vijayarangam, Varshini, Deviparasakthi, Mangayer Karasi Gopalakrishnan, Wahab, Mugip Rahaman Abdul, Surendran, Hemapreethi. 2024. Implications and progression of peroxiredoxin 2 (PRDX2) in various human diseases. In Pathology, research and practice, 254, 155080. doi:10.1016/j.prp.2023.155080. https://pubmed.ncbi.nlm.nih.gov/38219498/
3. Zhang, Mengqi, Shi, Xiaofeng, Tang, Minglei, Luo, Cheng, Xie, Xiangyang. 2024. PRDX2 deficiency increases MCD-induced nonalcoholic steatohepatitis in female mice. In Biochemical and biophysical research communications, 701, 149589. doi:10.1016/j.bbrc.2024.149589. https://pubmed.ncbi.nlm.nih.gov/38309152/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen