C57BL/6JCya-Prtn3em1/Cya
Common Name:
Prtn3-KO
Product ID:
S-KO-17518
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Prtn3-KO
Strain ID
KOCMP-19152-Prtn3-B6J-VA
Gene Name
Product ID
S-KO-17518
Gene Alias
PR-3; PR3; mPR3
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
10
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Prtn3em1/Cya mice (Catalog S-KO-17518) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000006679
NCBI RefSeq
NM_011178.2
Target Region
Exon 2
Size of Effective Region
~166 bp
Detailed Document
Overview of Gene Research
Prtn3, also known as proteinase 3, is an enzyme involved in various biological processes. It has been associated with multiple signaling pathways such as the PI3K/AKT and P38/ERK pathways, and plays important roles in immunoinflammatory responses, cancer progression, and metabolic processes [1].
In a myeloid cells - specific Prtn3 - knockout mouse model, Prtn3 deficiency in macrophages was shown to remold the immunosuppressive tumor microenvironment and suppress tumor growth in lung adenocarcinoma. It was found that Prtn3 in macrophages promotes the M2 polarization of tumor - associated macrophages, enhancing IL33/Treg - mediated tumor immunosuppression [2]. In mice, genetic elimination of Prtn3 led to spontaneous myeloid differentiation. Prtn3 interacts with the N - terminal of STAT3, promoting STAT3 ubiquitination and degradation, thus acting as a negative regulator of STAT3 - dependent myeloid differentiation. Deficiency of Prtn3 in primary AML blasts promotes their differentiation into functional neutrophils, improving overall survival rates for recipients [3].
In conclusion, Prtn3 is involved in regulating myeloid differentiation and plays a role in the tumor microenvironment, influencing tumor immunosuppression and cancer progression. The use of Prtn3 - knockout and conditional - knockout mouse models has provided valuable insights into its functions in cancer and leukemia, highlighting its potential as a therapeutic target in these disease areas.
References:
1. Shi, Zheng-Rong, Duan, Yu-Xin, Cui, Fang, Tang, Wei, Liao, Rui. 2023. Integrated proteogenomic characterization reveals an imbalanced hepatocellular carcinoma microenvironment after incomplete radiofrequency ablation. In Journal of experimental & clinical cancer research : CR, 42, 133. doi:10.1186/s13046-023-02716-y. https://pubmed.ncbi.nlm.nih.gov/37231509/
2. Jiang, Jiayu, Chen, Huilin, Zhao, Chunxing, Chen, Chong, Luo, Yunping. 2025. PRTN3 promotes IL33/Treg-mediated tumor immunosuppression by enhancing the M2 polarization of tumor-associated macrophages in lung adenocarcinoma. In Cancer letters, 616, 217584. doi:10.1016/j.canlet.2025.217584. https://pubmed.ncbi.nlm.nih.gov/39993649/
3. Liu, Huan, Sun, Lu, Zhao, Hongfei, Cao, Yihai, Xu, Yuanfu. 2024. Proteinase 3 depletion attenuates leukemia by promoting myeloid differentiation. In Cell death and differentiation, 31, 697-710. doi:10.1038/s41418-024-01288-4. https://pubmed.ncbi.nlm.nih.gov/38589495/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen