C57BL/6JCya-Jamlem1/Cya
Common Name
Jaml-KO
Product ID
S-KO-17574
Backgroud
C57BL/6JCya
Strain ID
KOCMP-270152-Jaml-B6J-VB
When using this mouse strain in a publication, please cite “Jaml-KO Mouse (Catalog S-KO-17574) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Jaml-KO
Strain ID
KOCMP-270152-Jaml-B6J-VB
Gene Name
Product ID
S-KO-17574
Gene Alias
AMICA, Amica1, Crea7, Gm638
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 9
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000050020
NCBI RefSeq
NM_001005421
Target Region
Exon 5
Size of Effective Region
~1.4 kb
Overview of Gene Research
JAML, short for Junctional Adhesion Molecule-Like Protein, is a protein-coding gene. It plays diverse roles in multiple biological processes, associated with various signaling pathways such as SIRT1-mediated SREBP1, PI3K-AKT-mTOR, and is involved in T-cell activation, lipid metabolism, and immune-related processes [1,3,4,5]. Genetic models, especially gene knockout (KO) and conditional knockout (CKO) mouse models, are valuable for studying JAML's functions.
In DKD, podocyte-specific deletion of Jaml ameliorated podocyte injury and proteinuria, revealing its role in promoting DKD by modulating podocyte lipid metabolism [1]. In AKI, macrophage-specific and tubular cell-specific Jaml conditional knockout mice demonstrated that JAML promoted AKI mainly via a macrophage-dependent mechanism [2]. In cancer, endothelial-specific knockout of JAML in mice effectively inhibited tumour growth through normalizing tumour blood vessels, suggesting JAML promotes tumour progression by angiogenesis [6].
In conclusion, JAML is involved in multiple biological functions including lipid metabolism, immune-mediated processes, and cancer-related angiogenesis. The use of Jaml KO/CKO mouse models has provided crucial insights into its role in DKD, AKI, and cancer, highlighting its potential as a therapeutic target for these diseases.
References：
1. Fu, Yi, Sun, Yu, Wang, Mei, Zhang, Chun, Yi, Fan. 2020. Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism. In Cell metabolism, 32, 1052-1062.e8. doi:10.1016/j.cmet.2020.10.019. https://pubmed.ncbi.nlm.nih.gov/33186558/
2. Huang, Wei, Wang, Bi-Ou, Hou, Yun-Feng, Sun, Yu, Yi, Fan. 2022. JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism. In JCI insight, 7, . doi:10.1172/jci.insight.158571. https://pubmed.ncbi.nlm.nih.gov/35708906/
3. Fang, Yuying, Liu, Yanan, Dong, Zhilin, Yang, Jianmin, Sun, Meili. 2024. JAML overexpressed in colorectal cancer promotes tumour proliferation by activating the PI3K-AKT-mTOR signalling pathway. In Scientific reports, 14, 24514. doi:10.1038/s41598-024-75180-z. https://pubmed.ncbi.nlm.nih.gov/39424882/
4. Eschweiler, Simon, Wang, Alice, Ramírez-Suástegui, Ciro, Ottensmeier, Christian H, Vijayanand, Pandurangan. 2023. JAML immunotherapy targets recently activated tumor-infiltrating CD8+ T cells. In Cell reports, 42, 112040. doi:10.1016/j.celrep.2023.112040. https://pubmed.ncbi.nlm.nih.gov/36701231/
5. McGraw, Joseph M, Thelen, Flavian, Hampton, Eric N, Havran, Wendy L, Witherden, Deborah A. 2021. JAML promotes CD8 and γδ T cell antitumor immunity and is a novel target for cancer immunotherapy. In The Journal of experimental medicine, 218, . doi:10.1084/jem.20202644. https://pubmed.ncbi.nlm.nih.gov/34427588/
6. Liu, Yanan, Zheng, Yawen, Zhao, Xinchao, Yang, Jianmin, Sun, Meili. 2025. Targeting JAML promotes normalization of tumour blood vessels to antagonize tumour progression via FAK/SRC and VEGF/VEGFR2 signalling pathways. In Life sciences, 368, 123474. doi:10.1016/j.lfs.2025.123474. https://pubmed.ncbi.nlm.nih.gov/39983824/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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