C57BL/6JCya-Msx1em1/Cya
Common Name
Msx1-KO
Product ID
S-KO-17590
Backgroud
C57BL/6JCya
Strain ID
KOCMP-17701-Msx1-B6J-VA
Status
When using this mouse strain in a publication, please cite “Msx1-KO Mouse (Catalog S-KO-17590) were purchased from Cyagen.”
Product Type
Age
Genotype
Sex
Quantity
Basic Information
Strain Name
Msx1-KO
Strain ID
KOCMP-17701-Msx1-B6J-VA
Gene Name
Product ID
S-KO-17590
Gene Alias
msh, Hox7, Hox-7, Hox7.1
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
Chr 5
Phenotype
Datasheet
Application
--
Strain Description
Ensembl Number
ENSMUST00000063116
NCBI RefSeq
NM_010835
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Overview of Gene Research
Msx1, belonging to the muscle segment homeobox gene family, is a transcription factor crucial for multiple epithelial-mesenchymal interactions during vertebrate embryogenesis [2,3]. It plays pleiotropic roles in various tissues, regulating cellular proliferation, differentiation, and cell death. Msx1 is associated with pathways like the canonical Wnt signaling pathway, which is essential for certain developmental processes [1].
In tooth development, Msx1 -/- mice have revealed its key role in the "bud to cap" morphogenesis. Msx1 drives tooth development by controlling the expression of Wnt antagonists such as Dkk2 and Sostdc1. Genetic inactivation of Sostdc1 rescued maxillary molar morphogenesis in Msx1 -/- mice, and combined inactivation of Dkk2 and Sostdc1 rescued both maxillary and mandibular molar development in Msx1 -/-;Dkk2 -/-;Sostdc1 -/- mice [1]. In mandibular development, Msx1 -/- mice showed unfused and bifurcated rostral tips of the mandibular processes, along with reduced cell proliferation and down-regulated Bmp signaling, indicating its essentiality for proper mandibular tip formation [4].
In conclusion, Msx1 is essential for tooth and mandibular development as demonstrated by gene-knockout mouse models. These models have provided insights into the role of Msx1 in these processes, which could be relevant for understanding and potentially treating related congenital defects such as tooth agenesis and mandibular clefting.
References：
1. Lee, J-M, Qin, C, Chai, O H, Jiang, R, Kwon, H-J E. 2022. MSX1 Drives Tooth Morphogenesis Through Controlling Wnt Signaling Activity. In Journal of dental research, 101, 832-839. doi:10.1177/00220345211070583. https://pubmed.ncbi.nlm.nih.gov/35114852/
2. Paradowska-Stolarz, Anna. 2015. MSX1 gene in the etiology orofacial deformities. In Postepy higieny i medycyny doswiadczalnej (Online), 69, 1499-504. doi:. https://pubmed.ncbi.nlm.nih.gov/27259221/
3. Liang, Jia, Von den Hoff, Johannes, Lange, Joanna, Bian, Zhuan, Carels, Carine E L. 2016. MSX1 mutations and associated disease phenotypes: genotype-phenotype relations. In European journal of human genetics : EJHG, 24, 1663-1670. doi:10.1038/ejhg.2016.78. https://pubmed.ncbi.nlm.nih.gov/27381090/
4. Shibuya, Saori, Nakatomi, Mitsushiro, Kometani-Gunjigake, Kaori, Seta, Yuji, Kawamoto, Tatsuo. 2022. Msx1 is essential for proper rostral tip formation of the mouse mandible. In Biochemical and biophysical research communications, 642, 75-82. doi:10.1016/j.bbrc.2022.12.047. https://pubmed.ncbi.nlm.nih.gov/36566565/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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