C57BL/6JCya-Ttc39aos1em1/Cya
Common Name:
Ttc39aos1-KO
Product ID:
S-KO-17652
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ttc39aos1-KO
Strain ID
KOCMP-102635290-Ttc39aos1-B6J-VA
Gene Name
Product ID
S-KO-17652
Gene Alias
Gm12750; lincRNA-EPS
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
4
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ttc39aos1em1/Cya mice (Catalog S-KO-17652) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000247239
NCBI RefSeq
NR_131195
Target Region
Exon 2~4
Size of Effective Region
~2.7 kb
Detailed Document
Overview of Gene Research
Ttc39aos1 is a lncRNA. Although specific details about its essential function, associated pathways, and overall biological importance are not elaborated in the given reference, genetic models could potentially be used to study it further.
In a study analyzing microarray data of non-alcoholic fatty liver disease (NAFLD), a set of lncRNAs and mRNAs were found to be differentially expressed during the development of NAFLD. Specifically, lncRNA Ttc39aos1 was identified as a potentially crucial biomarker for NAFLD [1].
In conclusion, Ttc39aos1 shows promise as a biomarker for NAFLD, as indicated by the analysis of microarray data. Further research using gene knockout (KO) or conditional knockout (CKO) mouse models could potentially reveal more about its biological functions in the context of NAFLD and other related diseases.
References：
1. Ma, Tao-Tao, Huang, Cheng, Ni, Ying, Yang, You, Li, Jun. 2018. ATP Citrate Lyase and LncRNA NONMMUT010685 Play Crucial Role in Nonalcoholic Fatty Liver Disease Based on Analysis of Microarray Data. In Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 51, 871-885. doi:10.1159/000495384. https://pubmed.ncbi.nlm.nih.gov/30466110/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen