C57BL/6JCya-Ctsoem1/Cya
Common Name:
Ctso-KO
Product ID:
S-KO-17665
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
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Basic Information
Strain Name
Ctso-KO
Strain ID
KOCMP-229445-Ctso-B6J-VB
Gene Name
Product ID
S-KO-17665
Gene Alias
A330105D01Rik
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
3
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ctsoem1/Cya mice (Catalog S-KO-17665) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000029649
NCBI RefSeq
NM_177662
Target Region
Exon 4~5
Size of Effective Region
~3.4 kb
Detailed Document
Overview of Gene Research
Ctso, encoding Cathepsin O, is a cysteine proteinase from the papain superfamily. The gene consists of eight coding exons and seven introns, spanning more than 30 kb, and maps to chromosome 4q31-q32 [6]. Cathepsin O is likely involved in proteolytic processes and may play roles in various cellular functions related to protein degradation and turnover.
In recent research, Ctso has emerged as a potential biomarker in multiple disease contexts. In Prader-Willi syndrome, Ctso was among the proteins with differential expression in liver steatosis, showing a progressive increase from grade 1 to grade 3, and may be involved in related metabolic pathways [1]. In obese adolescents, Ctso was identified as a biomarker for liver steatosis, with its expression correlating with the steatosis degree [3]. In sepsis-associated ARDS, Ctso was expressed in immune cells, and along with HLA-DQA1, could potentially be used as core genes for predicting sepsis-related prognosis analysis [2]. Additionally, in ERα-positive breast cancer, SNPs near the Ctso gene were associated with tamoxifen sensitivity, as Ctso reduces the protein levels of BRCA1 through cysteine proteinase-mediated degradation, and the variant Ctso SNP genotypes confer resistance to tamoxifen [4]. A SNP near the Ctso gene was also found to be a poor prognostic factor in hormone receptor-positive breast cancer patients receiving adjuvant tamoxifen therapy [5].
In conclusion, Ctso, as a cysteine proteinase-encoding gene, shows its significance in various disease areas such as liver steatosis, sepsis-associated ARDS, and breast cancer. Studies related to Ctso, especially those on its SNP associations in breast cancer and its role as a biomarker in liver steatosis and sepsis-associated ARDS, provide valuable insights into disease mechanisms and potential diagnostic or prognostic strategies.
References:
1. Pascut, Devis, Giraudi, Pablo J, Banfi, Cristina, Grugni, Graziano, Sartorio, Alessandro. 2023. Proteome profiling identifies circulating biomarkers associated with hepatic steatosis in subjects with Prader-Willi syndrome. In Frontiers in endocrinology, 14, 1254778. doi:10.3389/fendo.2023.1254778. https://pubmed.ncbi.nlm.nih.gov/38034016/
2. Shen, Yu Zhou, Yao, Yan Dong, Li, Hai Li, Li, Yang, Hu, Ying Chun. 2025. CTSO and HLA-DQA1 as biomarkers in sepsis-associated ARDS: insights from RNA sequencing and immune infiltration analysis. In BMC infectious diseases, 25, 326. doi:10.1186/s12879-025-10726-8. https://pubmed.ncbi.nlm.nih.gov/40055592/
3. Giraudi, P J, Pascut, D, Banfi, C, Minocci, A, Sartorio, A. 2024. Serum proteome signatures associated with liver steatosis in adolescents with obesity. In Journal of endocrinological investigation, 48, 213-225. doi:10.1007/s40618-024-02419-x. https://pubmed.ncbi.nlm.nih.gov/39017916/
4. Cairns, Junmei, Ingle, James N, Wickerham, Lawrence D, Liu, Mohan, Wang, Liewei. 2017. SNPs near the cysteine proteinase cathepsin O gene (CTSO) determine tamoxifen sensitivity in ERα-positive breast cancer through regulation of BRCA1. In PLoS genetics, 13, e1007031. doi:10.1371/journal.pgen.1007031. https://pubmed.ncbi.nlm.nih.gov/28968398/
5. Hato, Yukari, Kondo, Naoto, Yoshimoto, Nobuyasu, Nakanishi, Ryoichi, Toyama, Tatsuya. 2015. Prognostic impact of a single-nucleotide polymorphism near the CTSO gene in hormone receptor-positive breast cancer patients. In International journal of clinical oncology, 21, 539-47. doi:10.1007/s10147-015-0913-5. https://pubmed.ncbi.nlm.nih.gov/26482374/
6. Santamaría, I, Pendás, A M, Velasco, G, López-Otín, C. . Genomic structure and chromosomal localization of the human cathepsin O gene (CTSO). In Genomics, 53, 231-4. doi:. https://pubmed.ncbi.nlm.nih.gov/9790772/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen