C57BL/6JCya-Zdhhc11em1/Cya
Common Name:
Zdhhc11-KO
Product ID:
S-KO-17738
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Zdhhc11-KO
Strain ID
KOCMP-71164-Zdhhc11-B6J-VA
Gene Name
Product ID
S-KO-17738
Gene Alias
4933421L13Rik; DHHC-11; Zdhhc20
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
13
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Zdhhc11em1/Cya mice (Catalog S-KO-17738) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000091493
NCBI RefSeq
NM_027704
Target Region
Exon 3
Size of Effective Region
~0.2 kb
Detailed Document
Overview of Gene Research
Zdhhc11, a member of the DHHC palmitoyl transferase family, is involved in palmitoylation, an important post-translational protein modification. It participates in various biological processes, including innate immune responses, lipid droplet homeostasis, and NF-κB signaling pathways. Zdhhc11 is also associated with the growth of several types of cancers, such as Burkitt lymphoma, Hodgkin lymphoma, and diffuse large B-cell lymphoma, as well as colorectal cancer [1,2,4,5].
Zdhhc11 knockout mice have been used to study its function. In Zdhhc11-deficient mice, NF-κB activity stimulated by IL-1β, LPS, and DNA virus infection was impaired, and serum IL6 levels were lower upon LPS and D-galactosamine treatment or HSV-1 infection compared to control mice. This indicates that Zdhhc11 positively regulates NF-κB signaling by enhancing TRAF6 oligomerization [1]. In another study, Zdhhc11-/-mice exhibited lower serum cytokine levels and higher lethality after HSV-1 infection, suggesting its importance in mediating MITA-dependent innate immune responses against DNA viruses [3].
In conclusion, Zdhhc11 plays a crucial role in multiple biological processes. Through gene-knockout mouse models, its functions in innate immune responses and NF-κB signaling have been revealed. These findings are relevant to understanding diseases related to abnormal immune responses and cancer development, providing insights into potential therapeutic strategies targeting Zdhhc11.
References:
1. Liu, Enping, Sun, Jiawei, Yang, Jing, Chen, Dahua, Sun, Qinmiao. 2021. ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization. In Frontiers in cell and developmental biology, 9, 710967. doi:10.3389/fcell.2021.710967. https://pubmed.ncbi.nlm.nih.gov/34490261/
2. Liu, Yichen, Zhao, Xing, Seitz, Annika, Ziel-Swier, Lotteke J Y M, Kluiver, Joost. 2024. Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity. In Scientific reports, 14, 8730. doi:10.1038/s41598-024-59443-3. https://pubmed.ncbi.nlm.nih.gov/38627588/
3. Liu, Ying, Zhou, Qian, Zhong, Li, Shu, Hong-Bing, Li, Shu. 2018. ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association. In Cellular & molecular immunology, 15, 907-916. doi:10.1038/cmi.2017.146. https://pubmed.ncbi.nlm.nih.gov/29429998/
4. Ziel-Swier, Lotteke J Y M, Liu, Yichen, Seitz, Annika, van den Berg, Anke, Kluiver, Joost. 2022. The Role of the MYC/miR-150/MYB/ZDHHC11 Network in Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma. In Genes, 13, . doi:10.3390/genes13020227. https://pubmed.ncbi.nlm.nih.gov/35205272/
5. Murakami, Yuki, Konishi, Hiroaki, Fujiya, Mikihiro, Tanabe, Hiroki, Okumura, Toshikatsu. 2022. Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization. In Cancer medicine, 11, 3643-3656. doi:10.1002/cam4.4738. https://pubmed.ncbi.nlm.nih.gov/35384384/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen