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C57BL/6JCya-Ddcem1/Cya
Common Name:
Ddc-KO
Product ID:
S-KO-17776
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
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Basic Information
Strain Name
Ddc-KO
Strain ID
KOCMP-13195-Ddc-B6J-VA
Gene Name
Ddc
Product ID
S-KO-17776
Gene Alias
Aadc
Background
C57BL/6JCya
NCBI ID
13195
Modification
Conventional knockout
Chromosome
11
Phenotype
MGI:94876
Document
Click here to download >>
Application
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Rare Disease Data Center >>
Note
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ddcem1/Cya mice (Catalog S-KO-17776) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000178704
NCBI RefSeq
NM_001190448
Target Region
Exon 7
Size of Effective Region
~1.5 kb
Detailed Document
Click here to download >>
Overview of Gene Research
Ddc, also known as aromatic-l-amino-acid decarboxylase (AADC), is an enzyme that converts L-Dopa to dopamine [2]. Dopamine is a significant signaling molecule in the neuroendocrine system [3]. Ddc is involved in the dopamine-synthesizing pathway, and dopamine's functions are far-reaching in the nervous system, influencing processes like movement, mood, and reward-based learning. Genetic models can be valuable in studying Ddc to understand its precise role in these processes.

In Parkinson's disease (PD) research, although tyrosine hydroxylase (TH) expression is reduced in dopaminergic neurons in the substantia nigra pars compacta (SNpc), Ddc expression is relatively spared. Activation of DDC-positive neurons in the SNpc of an A53T-mutated alpha-synuclein overexpression model of PD, achieved through DDC-promoter-driven chemogenetic means, significantly alleviated parkinsonian motor symptoms and rescued nigrostriatal TH expression. This indicates that dormant dopaminergic neurons expressing Ddc could be a potential therapeutic target for PD [1]. Also, in crayfish (Procambarus clarkii), knockdown of Pc-ddc led to changes in the expression of genes related to the Toll (TLRs) signaling pathway and ROS-related antioxidant enzyme genes after bacterial challenge, suggesting that Ddc plays important mediating roles in the neuroendocrine immune (NEI) system of crayfish [3].

In conclusion, Ddc is crucial for dopamine synthesis, playing significant roles in the neuroendocrine system. In the context of PD, it offers a potential therapeutic target, as seen from the mouse model studies. In addition, its role in the innate immune reactions of crayfish shows its diverse functions across species. Research on Ddc using genetic models helps to understand its function in specific biological processes and disease conditions, providing insights for potential therapeutic strategies.

References:
1. Seo, Dong-Chan, Ju, Yeon Ha, Seo, Jin-Ju, Lee, Seung Eun, Nam, Min-Ho. 2023. DDC-Promoter-Driven Chemogenetic Activation of SNpc Dopaminergic Neurons Alleviates Parkinsonian Motor Symptoms. In International journal of molecular sciences, 24, . doi:10.3390/ijms24032491. https://pubmed.ncbi.nlm.nih.gov/36768816/
2. Lotsios, Nikolaos S, Arvanitis, Nikolaos, Charonitakis, Alexandros G, Sideris, Diamantis C, Vassilacopoulou, Dido. 2023. Expression of Human L-Dopa Decarboxylase (DDC) under Conditions of Oxidative Stress. In Current issues in molecular biology, 45, 10179-10192. doi:10.3390/cimb45120635. https://pubmed.ncbi.nlm.nih.gov/38132481/
3. Lin, Sihan, Wang, Kai, Yang, Bingbing, Shen, Xiuli, Du, Zhiqiang. 2022. Dopamine receptor (DAR) and dopa decarboxylase (DDC) mediate hepatopancreas antibacterial innate immune reactions in Procambarus clarkii. In International journal of biological macromolecules, 214, 140-151. doi:10.1016/j.ijbiomac.2022.05.200. https://pubmed.ncbi.nlm.nih.gov/35679960/
Quality Control Standard
Sperm Test

Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.

Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.

Environmental Standards:SPF
Available Region:Global
Source:Cyagen
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