C57BL/6JCya-Ubxn4em1/Cya
Common Name:
Ubxn4-KO
Product ID:
S-KO-17816
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Ubxn4-KO
Strain ID
KOCMP-67812-Ubxn4-B6J-VB
Gene Name
Product ID
S-KO-17816
Gene Alias
1300013G12Rik; Ubxd2; mKIAA0242
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
1
Phenotype
Document
Application
--
Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Ubxn4em1/Cya mice (Catalog S-KO-17816) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000027592
NCBI RefSeq
NM_026390
Target Region
Exon 2
Size of Effective Region
~1.2 kb
Detailed Document
Overview of Gene Research
Ubxn4, a gene of significant biological interest, may be involved in multiple biological processes. It has been implicated in pathways such as cholesterol metabolism [2], and is associated with the ubiquitin-proteasome system, given its role as an interacting partner of proteins involved in processes like the degradation of desmin intermediate filaments (by interacting with ATAD1 and PLAA) [3], and regulation of the WNT secretory factor EVI/WLS (by being a novel interaction partner) [4].
In non-small cell lung carcinoma, RNA-sequencing analysis of macrophages from different tumor regions identified Ubxn4 as one of the novel molecules that could serve as a potential prognostic marker. Lower density of M1 tumor-associated macrophages (TAM) in the tumor center and certain TAM-tumor cell proximity patterns related to M2 TAM were associated with poor survival, and Ubxn4 was among the genes potentially involved in this prognosis [1]. In the context of obesity and metabolic disorders, Ubxn4 was identified as one of the genes shared between obesity susceptibility and metabolic disorder susceptibility. Mendelian randomization and colocalization analyses suggested it has causal associations with these conditions [2].
In conclusion, Ubxn4 appears to be involved in crucial biological functions related to metabolism and disease prognosis. Its role in non-small cell lung carcinoma prognosis and its association with obesity and metabolic disorders, as revealed through these studies, highlight its importance in understanding disease mechanisms, potentially providing new targets for pharmacological intervention in these disease areas.
References:
1. Zheng, Xiang, Weigert, Andreas, Reu, Simone, Winter, Hauke, Savai, Rajkumar. 2020. Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small Cell Lung Carcinoma. In Cancer research, 80, 4414-4425. doi:10.1158/0008-5472.CAN-20-0069. https://pubmed.ncbi.nlm.nih.gov/32699134/
2. Fu, Liwan, Han, Xiaodi, Wang, Yuquan, Hu, Yue-Qing. 2025. Identifying genetic overlaps in obesity and metabolic disorders unlocking unique and shared mechanistic insights. In Free radical biology & medicine, 231, 80-93. doi:10.1016/j.freeradbiomed.2025.02.033. https://pubmed.ncbi.nlm.nih.gov/39999931/
3. Aweida, Dina, Cohen, Shenhav. 2022. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. In EMBO reports, 23, e55175. doi:10.15252/embr.202255175. https://pubmed.ncbi.nlm.nih.gov/36278411/
4. Wolf, Lucie M, Lambert, Annika M, Haenlin, Julie, Boutros, Michael. 2021. EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2. In Journal of cell science, 134, . doi:10.1242/jcs.257790. https://pubmed.ncbi.nlm.nih.gov/34406391/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen