C57BL/6JCya-Yes1em1/Cya
Common Name:
Yes1-KO
Product ID:
S-KO-17835
Background:
C57BL/6JCya
Product Type
Age
Genotype
Sex
Quantity
Price:
Contact for Pricing
Basic Information
Strain Name
Yes1-KO
Strain ID
KOCMP-22612-Yes1-B6J-VA
Gene Name
Product ID
S-KO-17835
Gene Alias
Yes; p61-Yes
Background
C57BL/6JCya
NCBI ID
Modification
Conventional knockout
Chromosome
5
Phenotype
Document
Application
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Note: When using this mouse strain in a publication, please cite “C57BL/6JCya-Yes1em1/Cya mice (Catalog S-KO-17835) were purchased from Cyagen.”
Strain Description
Ensembl Number
ENSMUST00000072311
NCBI RefSeq
NM_009535
Target Region
Exon 3
Size of Effective Region
~1.0 kb
Detailed Document
Overview of Gene Research
YES1, a nonreceptor tyrosine kinase, belongs to the SRC family of kinases (SFK) [1,2,5]. It controls multiple cancer-related signaling pathways, and is of great biological importance in tumorigenesis. YES1 is involved in pathways promoting cell proliferation, survival, invasion, and angiogenesis during cancer development [2]. Genetic models, such as gene knockout (KO) or conditional knockout (CKO) mouse models, could potentially be used to further study its functions.
Genetic depletion of YES1 in in vitro and in vivo models significantly reduced cell proliferation, three-dimensional organoid formation, tumor growth, and distant metastasis, leading to extensive apoptosis and tumor regressions in small-cell lung cancer (SCLC) [4]. In triple-negative breast cancer (TNBC), disrupting YES1, either genetically or pharmacologically, induced aberrant mitosis, centrosome amplification, multipolar spindles, and chromosomal instability [6]. In gastric cancer, knockdown of YES1 decreased cell invasion and migration in vitro and tumor growth in mouse models [3].
In conclusion, YES1 plays a pivotal role in promoting cancer cell proliferation, survival, and invasiveness across various cancer types, as revealed through model-based research. The use of KO/CKO mouse models in these studies has provided insights into the role of YES1 in SCLC, TNBC, and gastric cancer, suggesting that targeting YES1 could be a promising strategy for cancer treatment [1,3,4,6].
References:
1. Garmendia, Irati, Redin, Esther, Montuenga, Luis M, Calvo, Alfonso. . YES1: A Novel Therapeutic Target and Biomarker in Cancer. In Molecular cancer therapeutics, 21, 1371-1380. doi:10.1158/1535-7163.MCT-21-0958. https://pubmed.ncbi.nlm.nih.gov/35732509/
2. Zhou, Hai, Sun, Dantong, Tao, Junyan, Zhang, Xiaochun, Hou, Helei. 2023. Role of YES1 signaling in tumor therapy resistance. In Cancer innovation, 2, 210-218. doi:10.1002/cai2.51. https://pubmed.ncbi.nlm.nih.gov/38089407/
3. Mao, Linfeng, Yuan, Weijie, Cai, Kaimei, Chen, Zhikang, Chen, Zihua. 2021. EphA2-YES1-ANXA2 pathway promotes gastric cancer progression and metastasis. In Oncogene, 40, 3610-3623. doi:10.1038/s41388-021-01786-6. https://pubmed.ncbi.nlm.nih.gov/33941853/
4. Redin, Esther, Garrido-Martin, Eva M, Valencia, Karmele, Montuenga, Luis M, Calvo, Alfonso. 2022. YES1 Is a Druggable Oncogenic Target in SCLC. In Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 17, 1387-1403. doi:10.1016/j.jtho.2022.08.002. https://pubmed.ncbi.nlm.nih.gov/35988891/
5. Kook, Eunjin, Chun, Kyung-Soo, Kim, Do-Hee. 2024. Emerging Roles of YES1 in Cancer: The Putative Target in Drug Resistance. In International journal of molecular sciences, 25, . doi:10.3390/ijms25031450. https://pubmed.ncbi.nlm.nih.gov/38338729/
6. Piemonte, Katrina M, Ingles, Natasha N, Weber-Bonk, Kristen L, Singh, Salendra, Keri, Ruth A. . Targeting YES1 Disrupts Mitotic Fidelity and Potentiates the Response to Taxanes in Triple-Negative Breast Cancer. In Cancer research, 84, 3556-3573. doi:10.1158/0008-5472.CAN-23-2558. https://pubmed.ncbi.nlm.nih.gov/39037997/
Quality Control Standard
Sperm Test
Pre-cryopreservation: Measurement of sperm concentration, determination of sperm viability.
Post-cryopreservation: A vial of cryopreserved sperms is selected for in-vitro fertilization from each batch.
Environmental Standards:SPF
Available Region:Global
Source:Cyagen